-1.8 C
United States of America
Thursday, February 6, 2025

Theranostic nanoemulsions suppress macrophage-mediated acute irritation in rats | Journal of Nanobiotechnology


  • Medzhitov R. Origin and physiological roles of irritation. Nature. 2008;454(7203):428–35.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Oishi Y, Manabe I. Macrophages in irritation, restore and regeneration. Int Immunol. 2018;30(11):511–28.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Fujiwara N, Kobayashi Ok. Macrophages in irritation. Curr Drug Targets-Irritation Allergy. 2005;4(3):281–6.

    Article 
    CAS 

    Google Scholar
     

  • Shapouri-Moghaddam A, Mohammadian S, Vazini H, Taghadosi M, Esmaeili SA, Mardani F, Seifi B, Mohammadi A, Afshari JT, Sahebkar A. Macrophage plasticity, polarization, and performance in well being and illness. J Cell Physiol. 2018;233(9):6425–40.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhu L, Zhao Q, Yang T, Ding W, Zhao Y. Mobile metabolism and macrophage purposeful polarization. Int Rev Immunol. 2015;34(1):82–100.

    Article 
    PubMed 

    Google Scholar
     

  • Yunna C, Mengru H, Lei W, Weidong C. Macrophage M1/M2 polarization. Eur J Pharmacol. 2020;877:173090.

    Article 
    PubMed 

    Google Scholar
     

  • Schultze JL, Schmieder A, Goerdt S. Macrophage activation in human illnesses, seminars in Immunology. Elsevier; 2015. pp. 249–56.

  • Liu L, Karagoz H, Herneisey M, Zor F, Komatsu T, Loftus S, Janjic BM, Gorantla VS, Janjic JM. Intercourse variations revealed in a mouse CFA irritation mannequin with macrophage focused nanotheranostics. Theranostics. 2020;10(4):1694.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lin J, Ren J, Zhu B, Dai Y, Gao DS, Xia S, Cheng Z, Huang Y, Yu L. Dimethyl itaconate attenuates CFA-induced inflammatory ache through the NLRP3/IL-1β signaling pathway. Entrance Pharmacol. 2022;13:938979.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Deng L, He S, Guo N, Tian W, Zhang W, Luo L. Molecular mechanisms of ferroptosis and relevance to irritation. Inflamm Res. 2023;72(2):281–99.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bin S, Xin L, Lin Z, Jinhua Z, Rui G, Xiang Z. Concentrating on miR-10a-5p/IL-6R axis for decreasing IL-6-induced cartilage cell ferroptosis. Exp Mol Pathol. 2021;118:104570.

    Article 
    CAS 

    Google Scholar
     

  • Yan H-f, Zou T, Tuo Q-z, Xu S, Li H, Belaidi AA. Lei, Ferroptosis: mechanisms and hyperlinks with illnesses. Sign Transduct Goal Remedy. 2021;6(1):49.

    Article 
    CAS 

    Google Scholar
     

  • Guerrero-Hue M, García‐Caballero C, Palomino‐Antolín A, Rubio‐Navarro A, Vázquez‐Carballo C, Herencia C, Martín‐Sanchez D, Farré‐Alins V, Egea J, Cannata P. Curcumin reduces renal harm related to rhabdomyolysis by lowering ferroptosis‐mediated cell demise. FASEB J. 2019;33(8):8961–75.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tang X, Ding H, Liang M, Chen X, Yan Y, Wan N, Chen Q, Zhang J, Cao J. Curcumin induces ferroptosis in non-small‐cell lung most cancers through activating autophagy. Thorac Most cancers. 2021;12(8):1219–30.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kose T, Vera-Aviles M, Sharp PA, Latunde-Dada GO. Curcumin and (–)-epigallocatechin-3-gallate defend murine MIN6 pancreatic beta-cells in opposition to iron toxicity and erastin-induced ferroptosis. Prescribed drugs. 2019;12(1):26.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li J, Li L, Zhang Z, Chen P, Shu H, Yang C, Chu Y, Liu J. Ferroptosis: an essential participant within the inflammatory response in diabetic nephropathy. Entrance Immunol. 2023;14:1294317.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St CM, Croix Ok, Mikulska-Ruminska B, Liu IH, Shrivastava. Redox lipid reprogramming instructions susceptibility of macrophages and microglia to ferroptotic demise. Nat Chem Biol. 2020;16(3):278–90.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Laurindo LF, de Carvalho GM, de Oliveira Zanuso B, Figueira ME, Direito R, de Alvares R, Goulart DS, Buglio SM, Barbalho. Curcumin-based nanomedicines within the therapy of Inflammatory and Immunomodulated illnesses: an evidence-based Complete Evaluate. Pharmaceutics. 2023;15(1):229.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yin H, Guo Q, Li X, Tang T, Li C, Wang H, Solar Y, Feng Q, Ma C, Gao C. Curcumin suppresses IL-1β secretion and prevents irritation by way of inhibition of the NLRP3 inflammasome. J Immunol. 2018;200(8):2835–46.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gong Z, Zhou J, Li H, Gao Y, Xu C, Zhao S, Chen Y, Cai W, Wu J. Curcumin suppresses NLRP3 inflammasome activation and protects in opposition to LPS-induced septic shock. Mol Nutr Meals Res. 2015;59(11):2132–42.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Abdollahi E, Momtazi AA, Johnston TP, Sahebkar A. Therapeutic results of curcumin in inflammatory and immune-mediated illnesses: a nature‐made Jack‐of‐all‐trades? J Cell Physiol. 2018;233(2):830–48.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Mohammadi A, Blesso CN, Barreto GE, Banach M, Majeed M, Sahebkar A. Macrophage plasticity, polarization and performance in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent. J Nutr Biochem. 2019;66:1–16.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gao S, Zhou J, Liu N, Wang L, Gao Q, Wu Y, Zhao Q, Liu P, Wang S, Liu Y. Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13. J Mol Cell Cardiol. 2015;85:131–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Chen F, Guo N, Cao G, Zhou J, Yuan Z. Molecular evaluation of curcumin-induced polarization of murine RAW264. 7 macrophages. J Cardiovasc Pharmacol. 2014;63(6):544–52.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhou Y, Jia Z, Wang J, Huang S, Yang S, Xiao S, Xia D, Zhou Y. Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2, Heliyon. 2023;9(10).

  • Yang C, Han M, Li R, Zhou L, Zhang Y, Duan L, Su S, Li M, Wang Q, Chen T. Curcumin nanoparticles inhibiting ferroptosis for the improved therapy of intracerebral hemorrhage. Int J Nanomed (2021) 8049–65.

  • Li Y, Cai Z, Ma W, Bai L, Luo E, Lin Y. A DNA tetrahedron-based ferroptosis-suppressing nanoparticle: superior supply of curcumin and alleviation of diabetic osteoporosis. Bone Res. 2024;12(1):14.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hewlings SJ, Kalman DS. Curcumin: a evaluate of its results on human well being. Meals. 2017;6(10):92.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dehzad MJ, Ghalandari H, Nouri M, Askarpour M. Antioxidant and anti inflammatory results of curcumin/turmeric supplementation in adults: a GRADE-assessed systematic evaluate and dose–response meta-analysis of randomized managed trials. Cytokine. 2023;164:156144.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Janjic JM, Vasudeva Ok, Saleem M, Stevens A, Liu L, Patel S, Pollock JA. Low-dose NSAIDs scale back ache through macrophage focused nanoemulsion supply to neuroinflammation of the sciatic nerve in rat. J Neuroimmunol. 2018;318:72–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vichare R, Crelli C, Liu L, McCallin R, Cowan A, Stratimirovic S, Herneisey M, Pollock JA, Janjic JM. Folate-conjugated near-infrared fluorescent perfluorocarbon nanoemulsions as theranostics for activated macrophage COX-2 inhibition. Sci Rep. 2023;13(1):15229.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Saleem M, Deal B, Nehl E, Janjic JM, Pollock JA. Nanomedicine-driven neuropathic ache aid in a rat mannequin is related to macrophage polarity and mast cell activation. Acta Neuropathol Commun. 2019;7:1–21.

    Article 
    CAS 

    Google Scholar
     

  • Stevens AM, Liu L, Bertovich D, Janjic JM, Pollock JA. Differential expression of neuroinflammatory mRNAs within the rat sciatic nerve following persistent constriction damage and pain-relieving nanoemulsion NSAID supply to infiltrating macrophages. Int J Mol Sci. 2019;20(21):5269.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Herneisey M, Janjic JM. A number of Linear Regression Predictive modeling of colloidal and fluorescence Stability of Theranostic Perfluorocarbon Nanoemulsions. Pharmaceutics. 2023;15(4):1103.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Vichare R, Crelli C, Liu L, Das AC, McCallin R, Zor F, Kulahci Y, Gorantla VS, Janjic JM. A Reversibly Thermoresponsive, Theranostic Nanoemulgel for Tacrolimus Supply to activated macrophages: Formulation and in Vitro Validation. Pharmaceutics. 2023;15(10):2372.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Charaschanya M, Maskrey TS, LaPorte MG, Janjic JM, Wipf P. Synthesis and optimization of Nitroxide-based inhibitors of ferroptotic cell demise in Most cancers cells and macrophages. ACS Med Chem Lett. 2022;13(3):403–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Nichols JM, Crelli CV, Liu L, Pham HV, Janjic JM, Shepherd AJ. Monitoring macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy. J Neuroinflammation. 2021;18(1):299.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lambert E, Janjic JM. A number of linear regression utilized to predicting droplet measurement of complicated perfluorocarbon nanoemulsions for biomedical purposes. Pharm Dev Technol. 2019;24(6):700–10.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Herneisey M, Liu L, Lambert E, Schmitz N, Loftus S, Janjic JM. Growth of theranostic perfluorocarbon nanoemulsions as a mannequin non-opioid ache nanomedicine utilizing a high quality by design (QbD) strategy. AAPS PharmSciTech. 2019;20:1–13.

    Article 

    Google Scholar
     

  • Singh L, Sharma V. High quality by design (QbD) strategy in prescribed drugs: standing, challenges and subsequent steps. Drug Supply Lett. 2015;5(1):2–8.

    Article 

    Google Scholar
     

  • Adena SKR, Herneisey M, Pierce E, Hartmeier PR, Adlakha S, Hosfeld MA, Drennen JK, Janjic JM. High quality by design methodology utilized to course of optimization and scale up of curcumin nanoemulsions produced by catastrophic part inversion. Pharmaceutics. 2021;13(6):880.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kadayakkara DK, Ranganathan S, Younger W-B, Ahrens ET. Assaying macrophage exercise in a murine mannequin of inflammatory bowel illness utilizing fluorine-19 MRI. Lab Make investments. 2012;92(4):636–45.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Janjic JM, Srinivas M, Kadayakkara DK, Ahrens ET. Self-delivering nanoemulsions for twin fluorine-19 MRI and fluorescence detection. J Am Chem Soc. 2008;130(9):2832–41.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Schneider C, Gordon ON, Edwards RL, Luis PB. Degradation of curcumin: from mechanism to organic implications. J Agric Meals Chem. 2015;63(35):7606–14.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y-J, Pan M-H, Cheng A-L, Lin L-I, Ho Y-S, Hsieh C-Y, Lin J-Ok. Stability of curcumin in buffer options and characterization of its degradation merchandise. J Pharm Biomed Anal. 1997;15(12):1867–76.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Saleem M, Stevens AM, Deal B, Liu L, Janjic J, Pollock JA. A brand new finest observe for validating tail vein injections in rat with near-infrared-labeled brokers. JoVE (Journal Visualized Experiments). 2019;146:e59295.


    Google Scholar
     

  • Sou Ok, Inenaga S, Takeoka S, Tsuchida E. Loading of curcumin into macrophages utilizing lipid-based nanoparticles. Int J Pharm. 2008;352(1–2):287–93.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guo Y, Yang C, Zhang Y, Tao T. Nanomaterials for fluorescent detection of curcumin. Spectrochim Acta Half A Mol Biomol Spectrosc. 2022;265:120359.

    Article 
    CAS 

    Google Scholar
     

  • Kelmann RG, Kuminek G, Teixeira HF, Koester LS. Carbamazepine parenteral nanoemulsions ready by spontaneous emulsification course of. Int J Pharm. 2007;342(1–2):231–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ling Tan S, Stanslas J, Basri M, Karjiban A, Kirby RABP, Sani D, Bin H, Basri. Nanoemulsion-based parenteral drug supply system of carbamazepine: preparation, characterization, stability analysis and blood-brain pharmacokinetics. Curr Drug Deliv. 2015;12(6):795–804.

    Article 

    Google Scholar
     

  • Jin S, Meng C, He Y, Wang X, Zhang Q, Wang Z, Huang W, Wang H. Curcumin prevents osteocyte apoptosis by inhibiting M1-type macrophage polarization in mice mannequin of glucocorticoid‐related osteonecrosis of the femoral head. J Orthop Analysis®. 2020;38(9):2020–30.

    Article 
    CAS 

    Google Scholar
     

  • Lin C-H, Chen C-C, Chiang H-L, Liou J-M, Chang C-M, Lu T-P, Chuang EY, Tai Y-C, Cheng C, Lin H-Y. Altered intestine microbiota and inflammatory cytokine responses in sufferers with Parkinson’s illness. J Neuroinflamm. 2019;16:1–9.

    Article 

    Google Scholar
     

  • Raphael I, Nalawade S, Eagar TN, Forsthuber TG. T cell subsets and their signature cytokines in autoimmune and inflammatory illnesses. Cytokine. 2015;74(1):5–17.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Lan T, Chen L, Wei X. Inflammatory cytokines in most cancers: complete understanding and medical progress in gene remedy. Cells. 2021;10(1):100.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou Y-Q, Liu Z, Liu Z-H, Chen S-P, Li M, Shahveranov A, Ye D-W, Tian Y-Ok. Interleukin-6: an rising regulator of pathological ache. J Neuroinflamm. 2016;13:1–9.

    Article 

    Google Scholar
     

  • Solar S, Yin Y, Yin X, Cao F, Luo D, Zhang T, Li Y, Ni L. Anti-nociceptive results of Tanshinone IIA (TIIA) in a rat mannequin of full Freund’s adjuvant (CFA)-induced inflammatory ache. Mind Res Bull. 2012;88(6):581–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Su TF, Zhao YQ, Zhang LH, Peng M, Wu CH, Pei L, Tian B, Zhang J, Shi J, Pan HL. Electroacupuncture reduces the expression of proinflammatory cytokines in infected pores and skin tissues by way of activation of cannabinoid CB 2 receptors. Eur J Ache. 2012;16(5):624–35.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ip WE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory impact of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017;356(6337):513–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Sperlágh B, Haskó G, Németh Z, Vizi ES. ATP launched by LPS will increase nitric oxideproduction in uncooked 264.7 macrophage cell line viaP2Z P2X7 receptors. Neurochem Int. 1998;33(3):209–15.

    Article 
    PubMed 

    Google Scholar
     

  • Chen Y, Boettger MK, Reif A, Schmitt A, Üçeyler N, Sommer C. Nitric oxide synthase modulates CFA-induced thermal hyperalgesia by way of cytokine regulation in mice. Mol Ache. 2010;6:1744–8069.

    Article 

    Google Scholar
     

  • Chen X, Kang R, Kroemer G, Tang D. Ferroptosis in an infection, irritation, and immunity. J Exp Med 218(6) (2021).

  • Yang Y, Wang Y, Guo L, Gao W, Tang T-L, Yan M. Interplay between macrophages and ferroptosis. Cell Demise Dis. 2022;13(4):355.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kim EH, Wong S-W, Martinez J. Programmed necrosis and illness: we interrupt your common programming to convey you necroinflammation. Cell Demise Differ. 2019;26(1):25–40.

    Article 
    PubMed 

    Google Scholar
     

  • Deal BS, Reynolds LM, Janjic JM, Pollock JA. Intercourse variations in habits and immune response revealed by a NSAID nanotherapeutic therapy throughout peripheral neuroinflammation. FASEB J 36 (2022).

  • Craft RM, Hewitt KA, Britch SC. Antinociception produced by nonsteroidal anti-inflammatory medication in feminine vs male rats. Behav Pharmacol. 2021;32(23):153–69.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bisht S, Maitra A. Systemic supply of curcumin: twenty first century options for an historic conundrum. Curr Drug Discov Technol. 2009;6(3):192–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Holder GM, Plummer JL, Ryan AJ. The metabolism and excretion of curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) within the rat. Xenobiotica. 1978;8(12):761–8.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Miao YM, Zhang YJ, Qiao SM, Xia YF, Wei ZF, Dai Y. Oral administration of curcumin ameliorates pulmonary fibrosis in mice by way of 15d-PGJ2-mediated induction of hepatocyte progress issue within the colon. Acta Pharmacol Sin. 2021;42(3):422–35.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, Howells L, Plummer S, Jukes R, Williams M, Steward WP, Gescher A. Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and within the rat in vivo, and analysis of their capability to inhibit phorbol ester-induced prostaglandin E2 manufacturing. Most cancers Res. 2001;61(3):1058–64.

    CAS 
    PubMed 

    Google Scholar
     

  • Trabace L, Roviezzo F, Rossi A. Intercourse variations in Inflammatory illnesses. Entrance Pharmacol. 2022;13:962869.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Related Articles

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    Latest Articles