Wang Ok, Yu C, Liu Y, Zhang W, Solar Y, Chen Y. Enhanced antiatherosclerotic efficacy of Statin-Loaded reconstituted Excessive-Density lipoprotein by way of ganglioside GM1 modification. ACS Biomater Sci Eng. 2018;4:952–62.
Robichaud S, Rasheed A, Pietrangelo A, Doyoung Kim A, Boucher DM, Emerton C, Vijithakumar V, Gharibeh L, Fairman G, Mak E, et al. Autophagy is differentially regulated in leukocyte and nonleukocyte foam cells throughout atherosclerosis. Circ Res. 2022;130:831–47.
Chen Y, Yu F, Zhang Y, Li M, Di M, Chen W, Liu X, Zhang Y, Zhang M. Conventional Chinese language medicine Tongxinluo attenuates lipidosis in Ox-LDL-Stimulated macrophages by enhancing Beclin-1-Induced autophagy. Entrance Pharmacol. 2021;12:673366.
Shao B, Han B, Zeng Y, Su D, Liu C. The roles of macrophage autophagy in atherosclerosis. Acta Pharmacol Sin. 2016;37:150–6.
Sukhorukov VN, Khotina VA, Chegodaev YS, Ivanova E, Sobenin IA, Orekhov AN. Lipid metabolism in macrophages: give attention to atherosclerosis. Biomedicines. 2020;8:262.
Zuo J, Guo S, Qin X. Bisdemethoxycurcumin suppresses the development of atherosclerosis and VSMC-derived foam cell formation by selling lipophagy. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:3659–70.
Tao J, Yang P, Xie L, Pu Y, Guo J, Jiao J, Solar L, Lu D. Gastrodin induces lysosomal biogenesis and autophagy to forestall the formation of froth cells by way of AMPK-FoxO1-TFEB signalling axis. J Cell Mol Med. 2021;25:5769–81.
Simonsen JB. Analysis of reconstituted high-density lipoprotein (rHDL) as a drug supply platform – an in depth survey of rHDL particles starting from biophysical properties to medical implications. Nanomedicine. 2016;12:2161–79.
Maugeais C, Annema W, Blum D, Mary J-L, Tietge UJF. rHDL administration will increase reverse ldl cholesterol transport in mice, however is just not additive on high of Ezetimibe or Cholestyramine remedy. Atherosclerosis. 2013;229:94–101.
Zanotti I, Potì F, Cuchel M. HDL and reverse ldl cholesterol transport in people and animals: classes from pre-clinical fashions and medical research. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867:159065.
Mo Z-C, Ren Ok, Liu X, Tang Z-L, Yi G-H. A high-density lipoprotein-mediated drug supply system. Adv Drug Deliv Rev. 2016;106:132–47.
Rong T, Wei B, Ao M, Zhao H, Li Y, Zhang Y, Qin Y, Zhou J, Zhou F, Chen Y. Enhanced Anti-Atherosclerotic efficacy of pH-Responsively releasable ganglioside GM3 delivered by reconstituted Excessive-Density lipoprotein. Int J Mol Sci. 2021;22:13624.
Delk SC, Chattopadhyay A, Escola-Gil JC, Fogelman AM, Reddy ST. Apolipoprotein mimetics in most cancers. Semin Most cancers Biol. 2021;73:158–68.
Ma X, Tune Q, Gao X. Reconstituted high-density lipoproteins: novel biomimetic nanocarriers for drug supply. Acta Pharm Sin B. 2018;8:51–63.
Li Y, Luo X, Hua Z, Xue X, Wang X, Pang M, Wang T, Lyu A, Liu Y. Apolipoproteins as potential communicators play an important position within the pathogenesis and remedy of early atherosclerosis. Int J Biol Sci. 2023;19:4493–510.
Park H-J, Kuai R, Jeon EJ, Search engine optimisation Y, Jung Y, Moon JJ, Schwendeman A, Cho S-W. Excessive-density lipoprotein-mimicking nanodiscs carrying peptide for enhanced therapeutic angiogenesis in diabetic hindlimb ischemia. Biomaterials. 2018;161:69–80.
Huang J-L, Jiang G, Tune Q-X, Gu X, Hu M, Wang X-L, Tune H-H, Chen L-P, Lin Y-Y, Jiang D, et al. Lipoprotein-biomimetic nanostructure permits environment friendly concentrating on supply of SiRNA to Ras-activated glioblastoma cells by way of macropinocytosis. Nat Commun. 2017;8:15144.
Kuai R, Li D, Chen YE, Moon JJ, Schwendeman A. Excessive-Density lipoproteins: Nature’s multifunctional nanoparticles. ACS Nano. 2016;10:3015–41.
Zhang W-L, Xiao Y, Liu J-P, Wu Z-M, Gu X, Xu Y-M, Lu H. Construction and transforming conduct of drug-loaded excessive density lipoproteins and their atherosclerotic plaque concentrating on mechanism in foam cell mannequin. Int J Pharm. 2011;419:314–21.
Vucic E, Rosenson RS. Recombinant high-density lipoprotein formulations. Curr Atheroscler Rep. 2011;13:81–7.
Tardy C, Goffinet M, Boubekeur N, Ackermann R, Sy G, Bluteau A, Cholez G, Keyserling C, Lalwani N, Paolini JF, et al. CER-001, a HDL-mimetic, stimulates the reverse lipid transport and atherosclerosis regression in excessive ldl cholesterol diet-fed LDL-receptor poor mice. Atherosclerosis. 2014;232:110–8.
Li Z, Zhang J, Duan X, Zhao G, Zhang M, Celastrol. A promising agent preventing towards cardiovascular illnesses. Antioxid (Basel). 2022;11:1597.
Tan J-L, Yi J, Cao X-Y, Wang F-Y, Xie S-L, Zhou L-L, Qin L, Dai A-G. Celastrol: The brand new daybreak within the remedy of vascular transforming illnesses. Biomed Pharmacother. 2023; 158:114177.
Gu J, Shi Y-N, Zhu N, Li H-F, Zhang C-J, Qin L. Celastrol features as an rising supervisor of lipid metabolism: mechanism and therapeutic potential. Biomed Pharmacother. 2023;164:114981.
Zhang Y, Geng C, Liu X, Li M, Gao M, Liu X, Fang F, Chang Y. Celastrol ameliorates liver metabolic injury attributable to a high-fat weight-reduction plan by way of Sirt1. Mol Metab. 2017;6:138–47.
Choi SK, Park S, Jang S, Cho HH, Lee S, You S, Kim S-H, Moon H-S. Cascade regulation of PPARγ(2) and C/EBPα signaling pathways by Celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes. Metabolism. 2016;65:646–54.
Igarashi M, Osuga J, Uozaki H, Sekiya M, Nagashima S, Takahashi M, Takase S, Takanashi M, Li Y, Ohta Ok, et al. The essential position of impartial ldl cholesterol ester hydrolase 1 in ldl cholesterol removing from human macrophages. Circ Res. 2010;107:1387–95.
Liu Ok, Czaja MJ. Regulation of lipid shops and metabolism by lipophagy. Cell Dying Differ. 2013;20:3–11.
Ouimet M, Franklin V, Mak E, Liao X, Tabas I, Marcel YL. Autophagy regulates ldl cholesterol efflux from macrophage foam cells by way of lysosomal acid lipase. Cell Metab. 2011;13:655–67.
Kumar S, Nanduri R, Bhagyaraj E, Kalra R, Ahuja N, Chacko AP, Tiwari D, Sethi Ok, Saini A, Chandra V, et al. Vitamin D3-VDR-PTPN6 axis mediated autophagy contributes to the Inhibition of macrophage foam cell formation. Autophagy. 2021;17:2273–89.
Ma Y, Huang Z, Zhou Z, He X, Wang Y, Meng C, Huang G, Fang N. A novel antioxidant Mito-Tempol inhibits ox-LDL-induced foam cell formation by way of restoration of autophagy flux. Free Radic Biol Med. 2018;129:463–72.
Zahid MDK, Rogowski M, Ponce C, Choudhury M, Moustaid-Moussa N, Rahman SM. CCAAT/enhancer-binding protein beta (C/EBPβ) knockdown reduces irritation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells. Mol Cell Biochem. 2020;463:211–23.
Liu L, He H, Zhang M, Zhang S, Zhang W, Liu J. Hyaluronic acid-decorated reconstituted excessive density lipoprotein concentrating on atherosclerotic lesions. Biomaterials. 2014;35:8002–14.
Wei B, Li Y, Ao M, Shao W, Wang Ok, Rong T, Zhou Y, Chen Y. Ganglioside GM3-Functionalized reconstituted Excessive-Density lipoprotein (GM3-rHDL) as a novel nanocarrier enhances antiatherosclerotic efficacy of Statins in apoE-/- C57BL/6 mice. Pharmaceutics. 2022;14:2534.
Jiang C, Wang X, Teng B, Wang Z, Li F, Zhao Y, Guo Y, Zeng Q. Peptide-Focused Excessive-Density lipoprotein nanoparticles for combinatorial remedy towards metastatic breast most cancers. ACS Appl Mater Interfaces. 2021;13:35248–65.
Wang W, Chen Ok, Su Y, Zhang J, Li M, Zhou J. Lysosome-Impartial intracellular drug/gene codelivery by Lipoprotein-Derived nanovector for synergistic Apoptosis-Inducing Most cancers-Focused remedy. Biomacromolecules. 2018;19:438–48.
Gu X, Zhang W, Liu J, Shaw JP, Shen Y, Xu Y, Lu H, Wu Z. Preparation and characterization of a lovastatin-loaded protein-free nanostructured lipid service resembling high-density lipoprotein and analysis of its concentrating on to foam cells. AAPS PharmSciTech. 2011;12:1200–8.
Xu S-W, Regulation BYK, Qu SLQ, Hamdoun S, Chen J, Zhang W, Guo J-R, Wu A-G, Mok SWF, Zhang DW, et al. SERCA and P-glycoprotein Inhibition and ATP depletion are mandatory for celastrol-induced autophagic cell loss of life and collateral sensitivity in multidrug-resistant tumor cells. Pharmacol Res. 2020;153:104660.
Cai C, Zhu H, Ning X, Li L, Yang B, Chen S, Wang L, Lu X, Gu D. LncRNA ENST00000602558.1 regulates ABCG1 expression and ldl cholesterol efflux from vascular easy muscle cells by way of a p65-dependent pathway. Atherosclerosis. 2019;285:31–9.
Jiang C, Qi Z, Tang Y, Jia H, Li Z, Zhang W, Liu J. Rational design of Lovastatin-Loaded spherical reconstituted excessive density lipoprotein for environment friendly and protected Anti-Atherosclerotic remedy. Mol Pharm. 2019;16:3284–91.
Nagy A, Zane A, Cole SL, Severance M, Dutta PK, Waldman WJ. Distinction of the organic exercise of negatively and positively charged microwave synthesized CdSe/ZnS quantum Dots. Chem Res Toxicol. 2011;24:2176–88.
Ekkelenkamp AE, Jansman MMT, Roelofs Ok, Engbersen JFJ, Paulusse JMJ. Surfactant-free Preparation of extremely secure zwitterionic poly(amido amine) nanogels with minimal cytotoxicity. Acta Biomater. 2016;30:126–34.
Tune X, Fischer P, Chen X, Burton C, Wang J. An apoA-I mimetic peptide facilitates off-loading ldl cholesterol from HDL to liver cells by way of scavenger receptor BI. Int J Biol Sci. 2009;5:637–46.
Liu Q, Wang Y-M, Gu H-F. Lipophagy in atherosclerosis. Clin Chim Acta. 2020;511:208–14.
Geng M-Y, Wang L, Tune Y-Y, Gu J, Hu X, Yuan C, Yang M, Pei W-J, Zhang Y, Gao J-L. Sidt2 is a key protein within the autophagy-lysosomal degradation pathway and is important for the upkeep of kidney construction and filtration perform. Cell Dying Dis. 2021;13:7.
Wang X, Wang C, Tian H, Chen Y, Wu B, Cheng W. IR-820@NBs mixed with MG-132 enhances the Anti-Hepatocellular carcinoma impact of sonodynamic remedy. Int J Nanomed. 2023;18:6199–212.
Zhao J, Hu B, Xiao H, Yang Q, Cao Q, Li X, Zhang Q, Ji A, Tune S. Fucoidan reduces lipid accumulation by selling foam cell autophagy by way of TFEB. Carbohydr Polym. 2021;268:118247.
Cruz ALS, Carrossini N, Teixeira LK, Ribeiro-Pinto LF, Bozza PT, Viola JPB. Cell cycle development regulates biogenesis and mobile localization of lipid droplets. Mol Cell Biol. 2019;39:e00374–18.
Mathiassen SG, De Zio D, Cecconi F. Autophagy and the cell cycle: A fancy panorama. Entrance Oncol. 2017;7:51.
Gschwind A, Marx C, Simply MD, Severin P, Behring H, Marx-Blümel L, Becker S, Rothenburger L, Förster M, Beck JF, et al. Tight affiliation of autophagy and cell cycle in leukemia cells. Cell Mol Biol Lett. 2022;27:32.
Morimoto Y, Saitoh S, Takayama Y. Development situations inducing G1 cell cycle arrest improve lipid manufacturing within the oleaginous yeast lipomyces starkeyi. J Cell Sci. 2022;135:jcs259996.
Wu H, Ploeger JM, Kamarajugadda S, Mashek DG, Mashek MT, Manivel JC, Shekels LL, Lapiro JL, Albrecht JH. Proof for a novel regulatory interplay involving Cyclin D1, lipid droplets, lipolysis, and cell cycle development in hepatocytes. Hepatol Commun. 2019;3:406–22.
Wang X, Li L, Niu X, Dang X, Li P, Qu L, Bi X, Gao Y, Hu Y, Li M, et al. mTOR enhances foam cell formation by suppressing the autophagy pathway. DNA Cell Biol. 2014;33:198–204.
Day EA, Ford RJ, Steinberg GR. AMPK as a therapeutic goal for treating metabolic illnesses. Tendencies Endocrinol Metab. 2017;28:545–60.
Ou H, Liu C, Feng W, Xiao X, Tang S, Mo Z. Position of AMPK in atherosclerosis by way of autophagy regulation. Sci China Life Sci. 2018;61:1212–21.
Qiao L, Zhang X, Liu M, Liu X, Dong M, Cheng J, Zhang X, Zhai C, Tune Y, Lu H, et al. Ginsenoside Rb1 enhances atherosclerotic plaque stability by bettering autophagy and lipid metabolism in macrophage foam cells. Entrance Pharmacol. 2017;8:727.
Varshney R, Varshney R, Mishra R, Gupta S, Sircar D, Roy P. Kaempferol alleviates palmitic acid-induced lipid shops, Endoplasmic reticulum stress and pancreatic β-cell dysfunction by way of AMPK/mTOR-mediated lipophagy. J Nutr Biochem. 2018;57:212–27.
Yoo J, Jeong I-Ok, Ahn KJ, Chung HY, Hwang Y-C. Fenofibrate, a PPARα agonist, reduces hepatic fats accumulation by way of the upregulation of TFEB-mediated lipophagy. Metabolism. 2021;120:154798.
Wei C-C, Luo Z, Hogstrand C, Xu Y-H, Wu L-X, Chen G-H, Pan Y-X, Tune Y-F. Zinc reduces hepatic lipid deposition and prompts lipophagy by way of Zn2+/MTF-1/PPARα and Ca2+/CaMKKβ/AMPK pathways. FASEB J 2018;fj201800463. On-line forward of print.
Ren T, Tang Y-J, Wang M-F, Wang H-S, Liu Y, Qian X, Chang C, Chen M-W. Triptolide induces apoptosis by way of the calcium/calmodulin–dependent protein kinase kinaseβ/AMP–activated protein kinase signaling pathway in non–small cell lung most cancers cells. Oncol Rep. 2020;44:2288–96.
Chen J, Li L, Li Y, Liang X, Solar Q, Yu H, Zhong J, Ni Y, Chen J, Zhao Z, et al. Activation of TRPV1 channel by dietary capsaicin improves visceral fats transforming by way of connexin43-mediated Ca2 + inflow. Cardiovasc Diabetol. 2015;14:22.
Xin S, Mueller C, Pfeiffer S, Kraft VAN, Merl-Pham J, Bao X, Feederle R, Jin X, Hauck SM, Schmitt-Kopplin P, et al. MS4A15 drives ferroptosis resistance by way of calcium-restricted lipid transforming. Cell Dying Differ. 2022;29:670–86.
Chauhan AS, Liu X, Jing J, Lee H, Yadav RK, Liu J, Zhou Y, Gan B. STIM2 interacts with AMPK and regulates calcium-induced AMPK activation. FASEB J. 2019;33:2957–70.
Yuan W, Fang W, Zhang R, Lyu H, Xiao S, Guo D, Ali DW, Michalak M, Chen X-Z, Zhou C, et al. Therapeutic methods concentrating on AMPK-dependent autophagy in most cancers cells. Biochim Biophys Acta Mol Cell Res. 2023;1870:119537.
Liu T-Y, Xiong X-Q, Ren X-S, Zhao M-X, Shi C-X, Wang J-J, Zhou Y-B, Zhang F, Han Y, Gao X-Y, et al. FNDC5 alleviates hepatosteatosis by restoring AMPK/mTOR-Mediated autophagy, fatty acid oxidation, and lipogenesis in mice. Diabetes. 2016;65:3262–75.
Wong VKW, Qiu C, Xu S-W, Regulation BYK, Zeng W, Wang H, Michelangeli F, Dias IRDSR, Qu YQ, Chan TW, et al. Ca2 + signalling performs a task in celastrol-mediated suppression of synovial fibroblasts of rheumatoid arthritis sufferers and experimental arthritis in rats. Br J Pharmacol. 2019;176:2922–44.
Pham TH, Lee GH, Jin SW, Lee SY, Han EH, Kim ND, Choi CY, Jeong G-S, Ki Lee S, Kim HS, et al. Sesamin ameliorates lipotoxicity and lipid accumulation by way of the activation of the Estrogen receptor alpha signaling pathway. Biochem Pharmacol. 2023;216:115768.
Laval T, Ouimet M. A job for lipophagy in atherosclerosis. Nat Rev Cardiol. 2023;20:431–2.
Diao Y, Clematichinenoside AR. Alleviates foam cell formation and the inflammatory response in Ox-LDL-Induced RAW264.7 cells by activating autophagy. Irritation. 2021;44:758–68.
Ouimet M, Marcel YL. Regulation of lipid droplet ldl cholesterol efflux from macrophage foam cells. Arterioscler Thromb Vasc Biol. 2012;32:575–81.
Xu H, Zhao H, Ding C, Jiang D, Zhao Z, Li Y, Ding X, Gao J, Zhou H, Luo C, et al. Celastrol suppresses colorectal most cancers by way of covalent concentrating on Peroxiredoxin 1. Sign Transduct Goal Ther. 2023;8:51.
Wagh PR, Desai P, Prabhu S, Wang J. Nanotechnology-Primarily based Celastrol formulations and their therapeutic purposes. Entrance Pharmacol. 2021;12:673209.
Wang B, Tang X, Yao L, Wang Y, Chen Z, Li M, Wu N, Wu D, Dai X, Jiang H, et al. Disruption of USP9X in macrophages promotes foam cell formation and atherosclerosis. J Clin Make investments. 2022;132:e154217.
Luo H, Wang J, Qiao C, Ma N, Liu D, Zhang W. Pycnogenol attenuates atherosclerosis by regulating lipid metabolism by way of the TLR4-NF-κB pathway. Exp Mol Med. 2015;47:e191.
Gu L, Bai W, Li S, Zhang Y, Han Y, Gu Y, Meng G, Xie L, Wang J, Xiao Y, et al. Celastrol prevents atherosclerosis by way of inhibiting LOX-1 and oxidative stress. PLoS ONE. 2013;8:e65477.
Shi Y-N, Liu L-P, Deng C-F, Zhao T-J, Shi Z, Yan J-Y, Gong Y-Z, Liao D-F, Qin L. Celastrol ameliorates vascular neointimal hyperplasia by way of Wnt5a-involved autophagy. Int J Biol Sci. 2021;17:2561–75.
Fan N, Zhao J, Zhao W, Zhang X, Tune Q, Shen Y, Shum HC, Wang Y, Rong J. Celastrol-loaded lactosylated albumin nanoparticles attenuate hepatic steatosis in non-alcoholic fatty liver illness. J Management Launch. 2022;347:44–54.
Xie Q, Zhao S, Li F. D-4F, an Apolipoprotein A-I mimetic peptide, promotes ldl cholesterol efflux from macrophages by way of ATP-binding cassette transporter A1. Tohoku J Exp Med. 2010;220:223–8.
Lin H-P, Singla B, Ahn W, Ghoshal P, Blahove M, Cherian-Shaw M, Chen A, Haller A, Hui DY, Dong Ok, et al. Receptor-independent fluid-phase macropinocytosis promotes arterial foam cell formation and atherosclerosis. Sci Transl Med. 2022;14:eadd2376.
Zhou M, Ren P, Zhang Y, Li S, Li M, Li P, Shang J, Liu W, Liu H. Shen-Yuan-Dan capsule attenuates atherosclerosis and foam cell formation by enhancing autophagy and inhibiting the PI3K/Akt/mTORC1 signaling pathway. Entrance Pharmacol. 2019;10:603.
Tang Y, Wu H, Shao B, Wang Y, Liu C, Guo M. Celosins inhibit atherosclerosis in ApoE-/- mice and promote autophagy move. J Ethnopharmacol. 2018;215:74–82.
Shi Y, Jiang S, Zhao T, Gong Y, Liao D, Qin L. Celastrol suppresses lipid accumulation by way of LXRα/ABCA1 signaling pathway and autophagy in vascular easy muscle cells. Biochem Biophys Res Commun. 2020;532:466–74.
Ma A, Wang J, Yang L, An Y, Zhu H. AMPK activation enhances the anti-atherogenic results of excessive density lipoproteins in apoE-/- mice. J Lipid Res. 2017;58:1536–47.
Chen M, Zhu J-Y, Mu W-J, Luo H-Y, Li Y, Li S, Yan L-J, Li R-Y, Guo L. Cdo1-Camkk2-AMPK axis confers the protecting results of train towards NAFLD in mice. Nat Commun. 2023;14:8391.
Li J, Wang X, Meng X, Zhou X, Huang H, Feng Y, Fu Y, Liu X, Yu B. Geraniin concentrating on CaMKK2 inhibits lipid accumulation in 3T3-L1 adipocytes by suppressing lipogenesis. Chem Biol Work together. 2023;372:110364.
Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, Shi Q, Zeng Ok, Guo W, Li C. CAMKK2 defines ferroptosis sensitivity of melanoma cells by regulating AMPK–NRF2 pathway. J Make investments Dermatol. 2022;142:189–e2008.
Giordano A, Murano I, Mondini E, Perugini J, Smorlesi A, Severi I, Barazzoni R, Scherer PE, Cinti S. Overweight adipocytes present ultrastructural options of confused cells and die of pyroptosis. J Lipid Res. 2013;54:2423–36.
Arruda AP, Hotamisligil GS. Calcium homeostasis and organelle perform within the pathogenesis of weight problems and diabetes. Cell Metab. 2015;22:381–97.
Bi J, Wang W, Liu Z, Huang X, Jiang Q, Liu G, Wang Y, Huang X. Seipin promotes adipose tissue fats storage by way of the ER Ca2+-ATPase SERCA. Cell Metab. 2014;19:861–71.
Shi W, Xu D, Gu J, Xue C, Yang B, Fu L, Tune S, Liu D, Zhou W, Lv J, et al. Saikosaponin-d inhibits proliferation by up-regulating autophagy by way of the CaMKKβ-AMPK-mTOR pathway in ADPKD cells. Mol Cell Biochem. 2018;449:219–26.
Masuda M, Yoshida-Shimizu R, Mori Y, Ohnishi Ok, Adachi Y, Sakai M, Kabutoya S, Ohminami H, Yamanaka-Okumura H, Yamamoto H, et al. Sulforaphane induces lipophagy by way of the activation of AMPK-mTOR-ULK1 pathway signaling in adipocytes. J Nutr Biochem. 2022;106:109017.
