Schapira, M., Calabrese, M. F., Bullock, A. N. & Crews, C. M. Focused protein degradation: increasing the toolbox. Nat. Rev. Drug Discov. 18, 949–963 (2019).
Chamberlain, P. P. & Hamann, L. G. Improvement of focused protein degradation therapeutics. Nat. Chem. Biol. 15, 937–944 (2019).
Zhao, L., Zhao, J., Zhong, Ok., Tong, A. & Jia, D. Focused protein degradation: mechanisms, methods and utility. Sign Transduct. Goal. Ther. 7, 113 (2022).
Hu, Z. & Crews, C. M. Current developments in PROTAC-mediated protein degradation: from bench to clinic. ChemBioChem 23, e202100270 (2022).
Takahashi, D. et al. AUTACs: cargo-specific degraders utilizing selective autophagy. Mol. Cell 76, 797–810.e10 (2019).
Ji, C. H. et al. The AUTOTAC chemical biology platform for focused protein degradation by way of the autophagy–lysosome system. Nat. Commun. 13, 904 (2022).
Garber, Ok. The PROTAC gold rush. Nat. Biotechnol. 40, 12–16 (2022).
Banik, S. M. et al. Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature 584, 291–297 (2020).
Marei, H. et al. Antibody focusing on of E3 ubiquitin ligases for receptor degradation. Nature 610, 182–189 (2022).
Zhang, P. et al. Most cancers nanomedicine towards medical translation: obstacles, alternatives, and future prospects. Med 4, 147–167 (2023).
Sousa de Almeida, M. et al. Understanding nanoparticle endocytosis to enhance focusing on methods in nanomedicine. Chem. Soc. Rev. 50, 5397–5434 (2021).
Donahue, N. D., Acar, H. & Wilhelm, S. Ideas of nanoparticle mobile uptake, intracellular trafficking, and kinetics in nanomedicine. Adv. Drug Deliv. Rev. 143, 68–96 (2019).
Gautam, L. et al. Multicompartment methods: a putative service for mixed drug supply and focusing on. Drug Discov. In the present day 27, 1184–1195 (2022).
Tsuchikama, Ok. & An, Z. Antibody–drug conjugates: latest advances in conjugation and linker chemistries. Protein Cell 9, 33–46 (2018).
Xu, M. J., Johnson, D. E. & Grandis, J. R. EGFR-targeted therapies within the post-genomic period. Most cancers Metastasis Rev. 36, 463–473 (2017).
Kjær, I. et al. Cetuximab resistance in squamous carcinomas of the higher aerodigestive tract is pushed by receptor tyrosine kinase plasticity: potential for mAb mixtures. Mol. Most cancers Ther. 15, 1614–1626 (2016).
Jiang, X. et al. Position of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape. Mol. Most cancers 18, 10 (2019).
Oh, D.-Y. & Bang, Y.-J. HER2-targeted therapies—a job past breast most cancers. Nat. Rev. Clin. Oncol. 17, 33–48 (2020).
Jackson, C. B., Farzan, M., Chen, B. & Choe, H. Mechanisms of SARS-CoV-2 entry into cells. Nat. Rev. Mol. Cell Biol. 23, 3–20 (2022).
Chen, Y. et al. ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker. Sign Transduct. Goal. Ther. 6, 315 (2021).
Devarakonda, C. Ok. V., Meredith, E., Ghosh, M. & Shapiro, L. H. Coronavirus receptors as immune modulators. J. Immunol. 206, 923–929 (2021).
Tenchov, R., Chicken, R., Curtze, A. E. & Zhou, Q. Lipid nanoparticles—from liposomes to mRNA vaccine supply, a panorama of analysis variety and development. ACS Nano 15, 16982–17015 (2021).
Iversen, T.-G., Skotland, T. & Sandvig, Ok. Endocytosis and intracellular transport of nanoparticles: current data and wish for future research. Nano In the present day 6, 176–185 (2011).
Ahn, G. et al. LYTACs that have interaction the asialoglycoprotein receptor for focused protein degradation. Nat. Chem. Biol. 17, 937–946 (2021).
Wang, R. et al. Molecular foundation of V-ATPase inhibition by bafilomycin A1. Nat. Commun. 12, 1782 (2021).
Zhao, Y. G., Codogno, P. & Zhang, H. Equipment, regulation and pathophysiological implications of autophagosome maturation. Nat. Rev. Mol. Cell Biol. 22, 733–750 (2021).
Collier, J. J. et al. Developmental penalties of faulty ATG7-mediated autophagy in people. N. Engl. J. Med. 384, 2406–2417 (2021).
Wang, W. & Hu, Z. Focusing on peptide-based probes for molecular imaging and analysis. Adv. Mater. 31, 1804827 (2019).
Huang, L. et al. Novel peptide inhibitors of angiotensin-converting enzyme 2. J. Biol. Chem. 278, 15532–15540 (2003).
Gao, C. et al. Autophagy negatively regulates Wnt signalling by selling dishevelled degradation. Nat. Cell Biol. 12, 781–790 (2010).
Islam, M. A. et al. Restoration of tumour-growth suppression in vivo by way of systemic nanoparticle-mediated supply of PTEN mRNA. Nat. Biomed. Eng. 2, 850–864 (2018).
Tomayko, M. M. & Reynolds, C. P. Dedication of subcutaneous tumor measurement in athymic (nude) mice. Most cancers Chemother. Pharmacol. 24, 148–154 (1989).