Sweeney MD, et al. Blood–mind barrier: from physiology to illness and again. Physiol Rev. 2019;99(1):21–78.
Engelhardt B, Sorokin L. The blood–mind and the blood–cerebrospinal fluid boundaries: perform and dysfunction. Semin Immunopathol. 2009;31(4):497–511.
Cui Y, et al. Mind endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability. Cell Rep. 2021;36(1): 109327.
Oldendorf WH, Brown WJ. Higher variety of capillary endothelial cell mitochondria in mind than in muscle. Proc Soc Exp Biol Med. 1975;149(3):736–8.
Lipinski CA. Drug-like properties and the causes of poor solubility and poor permeability. J Pharmacol Toxicol Strategies. 2000;44(1):235–49.
Pardridge WM. Drug concentrating on to the mind. Pharm Res. 2007;24(9):1733–44.
Choudhari M, et al. Evolving new-age methods to move therapeutics throughout the blood–mind–barrier. Int J Pharm. 2021;599: 120351.
Cosolo WC, et al. Blood–mind barrier disruption utilizing mannitol: time course and electron microscopy research. Am J Physiol. 1989;256(2 Pt 2):R443–7.
Bellavance MA, Blanchette M, Fortin D. Current advances in blood–mind barrier disruption as a CNS supply technique. AAPS J. 2008;10(1):166–77.
Del Vecchio G, et al. Sodium caprate transiently opens claudin-5-containing boundaries at tight junctions of epithelial and endothelial cells. Mol Pharm. 2012;9(9):2523–33.
Boye Ok, et al. Endothelial Unc5B controls blood–mind barrier integrity. Nat Commun. 2022;13(1):1169.
Villalba N, et al. Web site-specific opening of the blood–mind barrier by extracellular histones. J Neuroinflammation. 2020;17(1):281.
Kim DG, et al. Gintonin, a ginseng-derived exogenous lysophosphatidic acid receptor ligand, enhances blood–mind barrier permeability and mind supply. Int J Biol Macromol. 2018;114:1325–37.
Bartus RT, et al. Managed modulation of BBB permeability utilizing the bradykinin agonist, RMP-7. Exp Neurol. 1996;142(1):14–28.
Alonso A. Ultrasound-induced blood-brain barrier opening for drug supply. Entrance Neurol Neurosci. 2015;36:106–15.
Tung YS, et al. The mechanism of interplay between centered ultrasound and microbubbles in blood–mind barrier opening in mice. J Acoust Soc Am. 2011;130(5):3059–67.
Ashraf O, et al. Laser-induced thermal remedy in neuro-oncology: a assessment. World Neurosurg. 2018;112:166–77.
Li X, et al. Reversibly modulating the blood–mind barrier by laser stimulation of molecular-targeted nanoparticles. Nano Lett. 2021;21(22):9805–15.
Praca C, et al. A nanoformulation for the preferential accumulation in grownup neurogenic niches. J Management Launch. 2018;284:57–72.
Bouchet A, et al. Permeability of mind tumor vessels induced by uniform or spatially microfractionated synchrotron radiation therapies. Int J Radiat Oncol Biol Phys. 2017;98(5):1174–82.
Furtado D, et al. Overcoming the blood–mind barrier: the position of nanomaterials in treating neurological illnesses. Adv Mater. 2018;30(46): e1801362.
Search engine optimisation S, et al. Triculture mannequin of in vitro BBB and its software to check BBB‐related chemosensitivity and drug supply in glioblastoma. Adv Funct Mater. 2022;32(10):2106860.
Neuwelt EA, et al. Reversible osmotic blood–mind barrier disruption in people: implications for the chemotherapy of malignant mind tumors. Neurosurgery. 1980;7(1):44–52.
Rapoport SI. Osmotic opening of the blood–mind barrier: ideas, mechanism, and therapeutic purposes. Cell Mol Neurobiol. 2000;20(2):217–30.
Burks SR, et al. Blood–mind barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses. Proc Natl Acad Sci. 2021;118(18):e2021915118.
Abrahao A, et al. First-in-human trial of blood–mind barrier opening in amyotrophic lateral sclerosis utilizing MR-guided centered ultrasound. Nat Commun. 2019;10(1):4373.
Rezai AR, et al. Noninvasive hippocampal blood–mind barrier opening in Alzheimer’s illness with centered ultrasound. Proc Natl Acad Sci U S A. 2020;117(17):9180–2.
Kovacs ZI, et al. Disrupting the blood–mind barrier by centered ultrasound induces sterile irritation. Proc Natl Acad Sci U S A. 2017;114(1):E75–84.
Jung O, et al. Neuroinflammation related to ultrasound-mediated permeabilization of the blood–mind barrier. Developments Neurosci. 2022;45(6):459–70.
Hashimoto Y, Campbell M. Tight junction modulation on the blood–mind barrier: present and future views. Biochim Biophys Acta Biomembr. 2020;1862(9): 183298.
Wala Ok, Szlasa W, Saczko J, Rudno-Rudzińska J, Kulbacka J. Modulation of blood–mind barrier permeability by activating adenosine A2 receptors in oncological remedy. Biomolecules. 2021;11(5):633.
Carman AJ, et al. Adenosine receptor signaling modulates permeability of the blood–mind barrier. J Neurosci. 2011;31(37):13272–80.
Jackson S, et al. The impact of an adenosine A(2A) agonist on intra-tumoral concentrations of temozolomide in sufferers with recurrent glioblastoma. Fluids Limitations CNS. 2018;15(1):2.
Verheggen ICM, et al. Enhance in blood–mind barrier leakage in wholesome, older adults. Geroscience. 2020;42(4):1183–93.
Montagne A, et al. Blood–mind barrier breakdown within the getting old human hippocampus. Neuron. 2015;85(2):296–302.
Yang AC, et al. Physiological blood–mind transport is impaired with age by a shift in transcytosis. Nature. 2020;583(7816):425–30.
Galea I. The blood–mind barrier in systemic an infection and irritation. Cell Mol Immunol. 2021;18(11):2489–501.
Villeda SA, et al. Younger blood reverses age-related impairments in cognitive perform and synaptic plasticity in mice. Nat Med. 2014;20(6):659–63.
Villeda SA, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive perform. Nature. 2011;477(7362):90–4.
Busatto S, et al. The position of extracellular vesicles within the physiological and pathological regulation of the blood–mind barrier. FASEB Bioadv. 2021;3(9):665–75.
Lino MM, et al. Engineered extracellular vesicles as mind therapeutics. J Management Launch. 2021;338:472–85.
van Niel G, D’Angelo G, Raposo G. Shedding gentle on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.
de Abreu RC, et al. Native and bioengineered extracellular vesicles for cardiovascular therapeutics. Nat Rev Cardiol. 2020;17(11):685–97.
Morales-Prieto DM, et al. Small extracellular vesicles from peripheral blood of aged mice go the blood-brain barrier and induce glial cell activation. Cells. 2022;11(4):625.
de Abreu RC, et al. Exogenous loading of miRNAs into small extracellular vesicles. J Extracell Vesicles. 2021;10(10): e12111.
Cecchelli R, et al. A steady and reproducible human blood–mind barrier mannequin derived from hematopoietic stem cells. PLoS ONE. 2014;9(6): e99733.
Van Deun J, et al. The influence of disparate isolation strategies for extracellular vesicles on downstream RNA profiling. J Extracell Vesicles. 2014;3(1):24858.
Wei M, et al. Activated microglia exosomes mediated miR-383-3p promotes neuronal necroptosis via inhibiting ATF4 expression in intracerebral hemorrhage. Neurochem Res. 2021;46(6):1337–49.
Zeng H, et al. Overexpression of miR-383-3p protects cardiomyocytes towards hypoxia/reoxygenation damage through regulating PTEN/PI3K/AKT sign pathway. J Biochem Mol Toxicol. 2022;36(12): e23205.
Nossent AY, et al. SNPs in microRNA binding websites in 3’-UTRs of RAAS genes affect arterial blood strain and danger of myocardial infarction. Am J Hypertens. 2011;24(9):999–1006.
Fehlmann T, et al. Widespread illnesses alter the physiological age-related blood microRNA profile. Nat Commun. 2020;11(1):5958.
Mensa E, et al. Small extracellular vesicles ship miR-21 and miR-217 as pro-senescence effectors to endothelial cells. J Extracell Vesicles. 2020;9(1):1725285.
Huan T, et al. Age‐related micro RNA expression in human peripheral blood is related to all‐trigger mortality and age‐associated traits. Getting old Cell. 2018;17(1):e12687.
Zhang H, et al. Investigation of microRNA expression in human serum through the getting old course of. J Gerontol A Biol Sci Med Sci. 2015;70(1):102–9.
Meder B, et al. Affect of the confounding elements age and intercourse on microRNA profiles from peripheral blood. Clin Chem. 2014;60(9):1200–8.
Olivieri F, et al. Age-related variations within the expression of circulating microRNAs: miR-21 as a brand new circulating marker of inflammaging. Mech Ageing Dev. 2012;133(11–12):675–85.
ElSharawy A, et al. Genome-wide miRNA signatures of human longevity. Getting old Cell. 2012;11(4):607–16.
Alibhai FJ, et al. Mobile senescence contributes to age-dependent adjustments in circulating extracellular vesicle cargo and performance. Getting old Cell. 2020;19(3): e13103.
Tsukamoto H, Kouwaki T, Oshiumi H. Getting old-associated extracellular vesicles include immune regulatory microRNAs assuaging hyperinflammatory state and immune dysfunction within the aged. Iscience. 2020;23(9):101520.
Fulzele S, et al. Muscle-derived miR-34a will increase with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells. Getting old (Albany NY). 2019;11(6):1791–803.
Raucci A, et al. MicroRNA-34a: the dangerous man in age-related vascular illnesses. Cell Mol Life Sci. 2021;78(23):7355–78.
Rani A, et al. miRNA in circulating microvesicles as biomarkers for age-related cognitive decline. Entrance Getting old Neurosci. 2017;9:323.
Carini G, et al. miRNome profiling detects miR-101-3p and miR-142-5p as putative blood biomarkers of frailty syndrome. Genes. 2022;13(2):231.
Zhang M, et al. miR-101-3p contributes to alpha-synuclein aggregation in neural cells via the miR-101-3p/SKP1/PLK2 pathway. J Healthc Eng. 2021;2021:6147434.
Zhao J, He Z, Wang J. MicroRNA-124: a key participant in microglia-mediated irritation in neurological illnesses. Entrance Cell Neurosci. 2021;15: 771898.
Guevremont D, et al. Plasma microRNA range in affiliation with the development of Alzheimer’s illness. Alzheimers Dement (Amst). 2022;14(1): e12251.
Jeyaseelan Ok, Lim KY, Armugam A. MicroRNA expression within the blood and mind of rats subjected to transient focal ischemia by center cerebral artery occlusion. Stroke. 2008;39(3):959–66.
Dimmeler S, Nicotera P. MicroRNAs in age-related illnesses. EMBO Mol Med. 2013;5(2):180–90.
Ryu IS, et al. The position of microRNA-485 in neurodegenerative illnesses. Rev Neurosci. 2023;34(1):49–62.
Zhang YH, Bai SF, Yan JQ. Blood circulating miRNAs as biomarkers of Alzheimer’s illness: a scientific assessment and meta-analysis. Biomark Med. 2019;13(12):1045–54.
Uwatoko H, et al. Identification of plasma microRNA expression adjustments in a number of system atrophy and Parkinson’s illness. Mol Mind. 2019;12(1):49.
Kumar S, et al. MicroRNAs as peripheral biomarkers in getting old and age-related illnesses. Prog Mol Biol Transl Sci. 2017;146:47–94.
Ma J, et al. Knockdown of lengthy non-coding RNA MALAT1 will increase the blood-tumor barrier permeability by up-regulating miR-140. Biochim Biophys Acta. 2016;1859(2):324–38.
Mishra R, Singh SK. HIV-1 Tat C modulates expression of miRNA-101 to suppress VE-cadherin in human mind microvascular endothelial cells. J Neurosci. 2013;33(14):5992–6000.
Wang Y, et al. MicroRNA-130a regulates cerebral ischemia-induced blood–mind barrier permeability by concentrating on Homeobox A5. FASEB J. 2018;32(2):935–44.
Yu H, et al. Knockdown of lengthy non-coding RNA XIST will increase blood-tumor barrier permeability and inhibits glioma angiogenesis by concentrating on miR-137. Oncogenesis. 2017;6(3): e303.
Bai Y, et al. Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse. Sci Rep. 2016;6:35642.
Cai H, et al. The lengthy noncoding RNA TUG1 regulates blood-tumor barrier permeability by concentrating on miR-144. Oncotarget. 2015;6(23):19759–79.
Fang Z, et al. MicroRNA-150 regulates blood–mind barrier permeability through Tie-2 after everlasting center cerebral artery occlusion in rats. FASEB J. 2016;30(6):2097–107.
Pena‐Philippides JC, Gardiner AS, Caballero‐Garrido E, Pan R, Zhu Y, Roitbak T. Inhibition of MicroRNA‐155 helps endothelial tight junction integrity following oxygen‐glucose deprivation. J Am Coronary heart Assoc. 2018;7(13):e009244.
Lopez-Ramirez MA, et al. MicroRNA-155 negatively impacts blood-brain barrier perform throughout neuroinflammation. FASEB J. 2014;28(6):2551–65.
Barker KR, et al. miR-155 modifies irritation, endothelial activation and blood–mind barrier dysfunction in cerebral malaria. Mol Med. 2017;23:24–33.
Ma J, et al. MiR-181a regulates blood-tumor barrier permeability by concentrating on Kruppel-like issue 6. J Cereb Blood Move Metab. 2014;34(11):1826–36.
Tominaga N, et al. Mind metastatic most cancers cells launch microRNA-181c-containing extracellular vesicles able to destructing blood-brain barrier. Nat Commun. 2015;6:6716.
Guo J, et al. Lengthy non-coding RNA NEAT1 regulates permeability of the blood-tumor barrier through miR-181d-5p-mediated expression adjustments in ZO-1, occludin, and claudin-5. Biochim Biophys Acta Mol Foundation Dis. 2017;1863(9):2240–54.
Miao YS, et al. MiR-18a elevated the permeability of BTB through RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5. Cell Sign. 2015;27(1):156–67.
Kalani A, et al. Function of microRNA29b in blood–mind barrier dysfunction throughout hyperhomocysteinemia: an epigenetic mechanism. J Cereb Blood Move Metab. 2014;34(7):1212–22.
Bukeirat M, et al. MiR-34a regulates blood–mind barrier permeability and mitochondrial perform by concentrating on cytochrome c. J Cereb Blood Move Metab. 2016;36(2):387–92.
Zhao W, et al. MiR-34a regulates blood-tumor barrier perform by concentrating on protein kinase Cepsilon. Mol Biol Cell. 2015;26(10):1786–96.
Zhao L, et al. miR-34c regulates the permeability of blood-tumor barrier through MAZ-mediated expression adjustments of ZO-1, occludin, and claudin-5. J Cell Physiol. 2015;230(3):716–31.
Chu Y, et al. Tetrandrine attenuates intestinal epithelial barrier defects attributable to colitis via selling the expression of Occludin through the AhR-miR-429 pathway. FASEB J. 2021;35(5): e21502.
Toyama Ok, et al. MicroRNA-mediated remedy modulating blood–mind barrier disruption improves vascular cognitive impairment. Arterioscler Thromb Vasc Biol. 2018;38(6):1392–406.
Leng X, et al. Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned regular BBB. J Exp Clin Most cancers Res. 2018;37(1):246.
Zhang W, et al. Exosomal miR-22-3p derived from power rhinosinusitis with nasal polyps regulates vascular permeability by concentrating on VE-cadherin. Biomed Res Int. 2020;2020:1237678.
Matsuoka H, et al. Ranges of tight junction protein CLDND1 are regulated by microRNA-124 within the cerebellum of stroke-prone spontaneously hypertensive rats. Biochem Biophys Res Commun. 2018;498(4):817–23.
Gu W, et al. MicroRNA-22 regulates irritation and angiogenesis through concentrating on VE-cadherin. FEBS Lett. 2017;591(3):513–26.
Xu B, et al. Neurons secrete miR-132-containing exosomes to control mind vascular integrity. Cell Res. 2017;27(7):882–97.
Burek M, et al. Hypoxia-induced microRNA-212/132 alter blood–mind barrier integrity via inhibition of tight junction-associated proteins in human and mouse mind microvascular endothelial cells. Transl Stroke Res. 2019;10(6):672–83.
Pei L, et al. Inhibition of MicroRNA-383 ameliorates damage after focal cerebral ischemia through concentrating on PPARgamma. Cell Physiol Biochem. 2016;39(4):1339–46.
Lin M, et al. miR-424-5p possibly regulate blood–mind barrier permeability in a mannequin in vitro with Abeta incubated endothelial cells. Biochem Biophys Res Commun. 2019;517(3):525–31.
Ma F, Zhang X, Yin KJ. MicroRNAs in central nervous system illnesses: a potential position in regulating blood–mind barrier integrity. Exp Neurol. 2020;323: 113094.
Zhou W, et al. Most cancers-secreted miR-105 destroys vascular endothelial boundaries to advertise metastasis. Most cancers Cell. 2014;25(4):501–15.
Muramatsu F, et al. microRNA-125b inhibits tube formation of blood vessels via translational suppression of VE-cadherin. Oncogene. 2013;32(4):414–21.
Lalwani MK, et al. Reverse genetics display in zebrafish identifies a job of miR-142a-3p in vascular improvement and integrity. PLoS ONE. 2012;7(12): e52588.
Younger JA, et al. Regulation of vascular leak and restoration from ischemic damage by basic and VE-cadherin-restricted miRNA antagonists of miR-27. Blood. 2013;122(16):2911–9.
Zhu Ok, et al. MiR-302c inhibits tumor development of hepatocellular carcinoma by suppressing the endothelial–mesenchymal transition of endothelial cells. Sci Rep. 2014;4:5524.
Wang Y, et al. Regulation of proliferation, angiogenesis and apoptosis in hepatocellular carcinoma by miR-26b-5p. Tumour Biol. 2016;37(8):10965–79.
Chen L, et al. VHL regulates the consequences of miR-23b on glioma survival and invasion through suppression of HIF-1alpha/VEGF and beta-catenin/Tcf-4 signaling. Neuro Oncol. 2012;14(8):1026–36.
Toyama Ok, Spin JM, Tsao PS. Function of microRNAs on blood mind barrier dysfunction in vascular cognitive impairment. Curr Drug Deliv. 2017;14(6):744–57.
Jakubec M, et al. Plasma-derived exosome-like vesicles are enriched in lyso-phospholipids and go the blood-brain barrier. PLoS ONE. 2020;15(9):e0232442.
Saleh AF, et al. Extracellular vesicles induce minimal hepatotoxicity and immunogenicity. Nanoscale. 2019;11(14):6990–7001.
Welsh JA, et al. Minimal data for research of extracellular vesicles (MISEV2023): from fundamental to superior approaches. J Extracell Vesicles. 2024;13(2):e12404.
Suidan GL, et al. Endothelial Von Willebrand issue promotes blood–mind barrier flexibility and supplies safety from hypoxia and seizures in mice. Arterioscler Thromb Vasc Biol. 2013;33(9):2112–20.
Hajal C, et al. Engineered human blood–mind barrier microfluidic mannequin for vascular permeability analyses. Nat Protoc. 2022;17(1):95–128.
Cucullo L, et al. Immortalized human mind endothelial cells and flow-based vascular modeling: a wedding of comfort for rational neurovascular research. J Cereb Blood Move Metab. 2008;28(2):312–28.
Cucullo L, et al. The position of shear stress in blood–mind barrier endothelial physiology. BMC Neurosci. 2011;12:40.
Kurokawa YK, et al. Human induced pluripotent stem cell-derived endothelial cells for three-dimensional microphysiological methods. Tissue Eng Half C Strategies. 2017;23(8):474–84.
Vatine GD, et al. Human iPSC-derived blood-brain barrier chips allow illness modeling and customized medication purposes. Cell Stem Cell. 2019;24(6):995–1005.
Morad G, et al. Tumor-derived extracellular vesicles breach the intact blood–mind barrier through transcytosis. ACS Nano. 2019;13(12):13853–65.
Aday S, et al. Stem cell-based human blood–mind barrier fashions for drug discovery and supply. Developments Biotechnol. 2016;34(5):382–93.
Lu Z, et al. Claudins in intestines: distribution and useful significance in well being and illnesses. Tissue Limitations. 2013;1(3): e24978.
Raya-Sandino A, et al. Claudin-23 reshapes epithelial tight junction structure to control barrier perform. Nat Commun. 2023;14(1):6214.
Cox KE, et al. The expression of the Claudin household of proteins in colorectal most cancers. Biomolecules. 2024;14(3):272.
Schlingmann B, Molina SA, Koval M. Claudins: Gatekeepers of lung epithelial perform. Semin Cell Dev Biol. 2015;42:47–57.
Nitta T, et al. Dimension-selective loosening of the blood–mind barrier in claudin-5-deficient mice. J Cell Biol. 2003;161(3):653–60.
Greene C, Hanley N, Campbell M. Claudin-5: gatekeeper of neurological perform. Fluids Limitations CNS. 2019;16(1):3.
Neill G, Masson GR. A keep of execution: ATF4 regulation and potential outcomes for the built-in stress response. Entrance Mol Neurosci. 2023;16:1112253.
Gerasymchuk M, et al. The position of microRNAs in organismal and pores and skin getting old. Int J Mol Sci. 2020;21(15):5281.
Petry A, et al. Cross discuss between p22phox and ATF4 within the endothelial unfolded protein response. Antioxid Redox Sign. 2019;30(1):40–55.
Puschel F, et al. Hunger and antimetabolic remedy promote cytokine launch and recruitment of immune cells. Proc Natl Acad Sci U S A. 2020;117(18):9932–41.
Afonyushkin T, et al. Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells through NRF2-dependent mechanism: novel level of convergence between electrophilic and unfolded protein stress pathways. Arterioscler Thromb Vasc Biol. 2010;30(5):1007–13.
Chen L, et al. Activating transcription issue 4 regulates angiogenesis underneath lipid overload through methionine adenosyltransferase 2A-mediated endothelial epigenetic alteration. FASEB J. 2021;35(6): e21612.
Fan Z, et al. Train-induced angiogenesis depends on metabolically primed ATF3/4+ endothelial cells. Cell Metab. 2021;33(9):1793–807.
Yasuda H, et al. Function of activating transcription issue 4 in murine choroidal neovascularization mannequin. Int J Mol Sci. 2021;22(16).
Noren Hooten N, et al. Influences of age, race, and intercourse on extracellular vesicle traits. Theranostics. 2022;12(9):4459–76.
Eitan E, et al. Age-related adjustments in plasma extracellular vesicle traits and internalization by leukocytes. Sci Rep. 2017;7(1):1342.
Zhang Y, et al. Hypothalamic stem cells management ageing velocity partly via exosomal miRNAs. Nature. 2017;548(7665):52–7.