Excessive-dose gold nanoparticle therapy outperformed orlistat in reversing obesity-related harm in rats, in accordance with analysis carried out by Alexandria College, Erbil Polytechnic College, and Pharos College.
Gold nanoparticles (AuNPs) demonstrated important anti-obesity results, decreasing physique fats, enhancing metabolic well being, and restoring organ operate in rats with diet-induced weight problems. The group in contrast the impression of AuNPs and orlistat, a generally used anti-obesity drug, on physique composition, metabolic parameters, and organ well being.
Weight problems is a metabolic dysfunction typically characterised by extra fats accumulation on account of an imbalance between caloric consumption and power expenditure. It’s related to elevated dangers of diabetes, heart problems, and demise.
The World Well being Group experiences that world weight problems charges have tripled since 1975, with Egypt rating 18th in grownup weight problems prevalence at 39.8%. Present therapies, together with orlistat, have restricted efficacy and undesirable unwanted side effects, prompting curiosity in various therapies comparable to AuNPs.
Within the examine, “Impact of Gold Nanoparticles Therapy on Rats-Induced Weight problems by Evaluating Physique-Composition Straight and Not directly by way of Bioelectric Impedance Evaluation,” revealed in Scientific Stories, researchers induced weight problems in 40 male Wistar Albino rats by feeding them a high-fat food plan for 9 weeks.
The rats have been then divided into therapy teams receiving both each day or weekly AuNPs injections at various doses or each day orlistat injections. A management group of eight rats was fed an ordinary food plan. Physique composition was assessed utilizing bioelectric impedance evaluation and dissection. Blood samples have been analyzed for lipid profiles, fasting blood glucose (FBG), and oxidative stress markers. Liver and kidney tissues have been examined histologically and ultrastructurally.
Researchers measured physique composition by way of bioelectric impedance evaluation and direct dissection. Excessive doses of gold nanoparticles decreased physique fats, elevated muscle mass, and restored biochemical parameters comparable to triglycerides, glucose, and oxidative-stress markers to near-normal ranges. These results have been extra pronounced in comparison with rats handled with orlistat or decrease doses of AuNPs.
Blood evaluation indicated that AuNPs therapy restored lipid profiles, FBG, and oxidative stress markers to regular ranges. Histological examination revealed that AuNPs decreased fats accumulation and improved liver and kidney cell construction, whereas orlistat-treated rats confirmed persistent organ harm.
Findings recommend that AuNPs might supply a promising various to standard weight problems therapies by enhancing metabolic parameters and decreasing organ harm. Additional analysis is required to find out their security and efficacy in human functions.
Extra info:
Rana M. Selima et al, Impact of gold nanoparticles therapy on rats-induced weight problems by evaluating body-composition instantly and not directly by way of bioelectric impedance evaluation, Scientific Stories (2025). DOI: 10.1038/s41598-025-87971-z
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