21.7 C
United States of America
Saturday, March 29, 2025

Biomimetic gene supply system coupled with extracellular vesicle–encapsulated AAV for bettering diabetic wound by means of selling vascularization and transforming of inflammatory microenvironment | Journal of Nanobiotechnology


  • Lee J, van der Valk WH, Serdy SA, Deakin C, Kim J, Le AP, Koehler KR. Technology and characterization of hair-bearing pores and skin organoids from human pluripotent stem cells. Nat Protoc. 2022;17(5):1266–305.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Matoori S, Veves A, Mooney DJ. Superior bandages for diabetic wound therapeutic. Sci Transl Med. 2021;13(585).

  • Sharifiaghdam M, Shaabani E, Faridi-Majidi R, De Smedt SC, Braeckmans Okay, Fraire JC. Macrophages as a therapeutic goal to advertise diabetic wound therapeutic. Mol Remedy: J Am Soc Gene Remedy. 2022;30(9):2891–908.

    CAS 

    Google Scholar
     

  • Dixon D, Edmonds M. Managing diabetic foot ulcers: pharmacotherapy for wound therapeutic. Medicine. 2021;81(1):29–56.

    CAS 
    PubMed 

    Google Scholar
     

  • Chang M, Nguyen TT. Technique for therapy of contaminated diabetic foot ulcers. Acc Chem Res. 2021;54(5):1080–93.

    CAS 
    PubMed 

    Google Scholar
     

  • Uemura A, Fruttiger M, D’Amore PA, De Falco S, Joussen AM, Sennlaub F, Brunck LR, Johnson KT, Lambrou GN, Rittenhouse KD, Langmann T. VEGFR1 signaling in retinal angiogenesis and microinflammation. Prog Retin Eye Res. 2021;84:100954.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jaipersad AS, Lip GY, Silverman S, Shantsila E. The function of monocytes in angiogenesis and atherosclerosis. J Am Coll Cardiol. 2014;63(1):1–11.

    CAS 
    PubMed 

    Google Scholar
     

  • Daseke MJ 2nd, Tenkorang MAA, Chalise U, Konfrst SR, Lindsey ML. Cardiac fibroblast activation throughout myocardial infarction wound therapeutic: fibroblast polarization after MI. Matrix Biology: J Int Soc Matrix Biology. 2020;91–2:109–116.

  • Ginn SL, Amaya AK, Alexander IE, Edelstein M, Abedi MR. Gene remedy scientific trials worldwide to 2017: an replace. J Gene Med. 2018;20(5):e3015.

    PubMed 

    Google Scholar
     

  • Smith RH. Adeno-associated virus integration: virus versus vector. Gene Ther. 2008;15(11):817–22.

    CAS 
    PubMed 

    Google Scholar
     

  • Niwano Okay, Arai M, Koitabashi N, Watanabe A, Ikeda Y, Miyoshi H, Kurabayashi M. Lentiviral vector-mediated SERCA2 gene switch protects towards coronary heart failure and left ventricular transforming after myocardial infarction in rats. Mol Remedy: J Am Soc Gene Remedy. 2008;16(6):1026–32.

    CAS 

    Google Scholar
     

  • Ribeil JA, Hacein-Bey-Abina S, Payen E, Magnani A, Semeraro M, Magrin E, Caccavelli L, Neven B, Bourget P, Nemer WE, Bartolucci P, Weber L, Puy H, Meritet JF, Grevent D, Beuzard Y, Chrétien S, Lefebvre T, Ross RW, Negre O, Veres G, Sandler L, Soni S, de Montalembert M, Blanche S, Leboulch P, Cavazzana M. Gene remedy in a affected person with sickle cell illness. N Engl J Med. 2017;376(9):848–55.

    CAS 
    PubMed 

    Google Scholar
     

  • Rangarajan S, Walsh L, Lester W, Perry D, Madan B, Laffan M, Yu H, Vettermann C, Pierce GF, Wong WY, Pasi KJ. AAV5-Issue VIII gene switch in extreme hemophilia A. N Engl J Med. 2017;377(26):2519–30.

    CAS 
    PubMed 

    Google Scholar
     

  • Greenberg B, Butler J, Felker GM, Ponikowski P, Voors AA, Desai AS, Barnard D, Bouchard A, Jaski B, Lyon AR, Pogoda JM, Rudy JJ, Zsebo KM. Calcium upregulation by percutaneous administration of gene remedy in sufferers with cardiac illness (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, section 2b trial. Lancet (London England). 2016;387(10024):1178–86.

    CAS 
    PubMed 

    Google Scholar
     

  • Jessup M, Greenberg B, Mancini D, Cappola T, Pauly DF, Jaski B, Yaroshinsky A, Zsebo KM, Dittrich H, Hajjar RJ. Calcium upregulation by percutaneous administration of gene remedy in cardiac illness (CUPID): a section 2 trial of intracoronary gene remedy of sarcoplasmic reticulum Ca2+-ATPase in sufferers with superior coronary heart failure. Circulation. 2011;124(3):304–13.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Valdmanis PN, Lisowski L, Kay MA. rAAV-mediated tumorigenesis: nonetheless unresolved after an AAV assault. Mol Remedy: J Am Soc Gene Remedy. 2012;20(11):2014–7.

    CAS 

    Google Scholar
     

  • Louis Jeune V, Joergensen JA, Hajjar RJ, Weber T. Pre-existing anti-adeno-associated virus antibodies as a problem in AAV gene remedy. Hum Gene Remedy Strategies. 2013;24(2):59–67.

    CAS 

    Google Scholar
     

  • Wang Z, Zhu T, Qiao C, Zhou L, Wang B, Zhang J, Chen C, Li J, Xiao X. Adeno-associated virus serotype 8 effectively delivers genes to muscle and coronary heart. Nat Biotechnol. 2005;23(3):321–8.

    CAS 
    PubMed 

    Google Scholar
     

  • Tang Q, Lu B, He J, Chen X, Fu Q, Han H, Luo C, Yin H, Qin Z, Lyu D, Zhang L, Zhou M, Yao Okay. Exosomes-loaded thermosensitive hydrogels for corneal epithelium and stroma regeneration. Biomaterials. 2022;280:121320.

    CAS 
    PubMed 

    Google Scholar
     

  • Bialik M, Kuras M, Sobczak M, Oledzka E. Achievements in thermosensitive gelling programs for rectal administration. Int J Mol Sci. 2021;22(11).

  • Dethe MR, Ahmed PAH, Agrawal M, Roy U, Alexander A. PCL-PEG copolymer primarily based injectable thermosensitive hydrogels. J Management Launch. 2022;343:217–36.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Aliakbari F, Marzookian Okay, Parsafar S, Hourfar H, Nayeri Z, Fattahi A, Raeiji M, Boroujeni NN, Otzen DE, Morshedi D. The influence of hUC MSC-derived exosome-nanoliposome hybrids on α-synuclein fibrillation and neurotoxicity. Sci Adv. 2024;10(14):eadl3406.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Guo G, Tan Z, Liu Y, Shi F, She J. The therapeutic potential of stem cell-derived exosomes within the ulcerative colitis and colorectal most cancers. Stem Cell Res Ther. 2022;13(1):138.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang S, Liang X, Music J, Li C, Liu A, Luo Y, Ma H, Tan Y, Zhang X. A novel therapeutic method for inflammatory bowel illness by exosomes derived from human umbilical twine mesenchymal stem cells to restore intestinal barrier through TSG-6. Stem Cell Res Ther. 2021;12(1):315.

    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bi Y, Qiao X, Liu Q, Music S, Zhu Okay, Qiu X, Zhang X, Jia C, Wang H, Yang Z, Zhang Y, Ji G. Systemic proteomics and MiRNA profile evaluation of exosomes derived from human pluripotent stem cells. Stem Cell Res Ther. 2022;13(1):449.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhang Z, Mi T, Jin L, Li M, Zhanghuang C, Wang J, Tan X, Lu H, Shen L, Lengthy C, Wei G, He D. Complete proteomic evaluation of exosome mimetic vesicles and exosomes derived from human umbilical twine mesenchymal stem cells. Stem Cell Res Ther. 2022;13(1):312.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang Okay, Li D, Wang M, Xu Z, Chen X, Liu Q, Solar W, Li J, Gong Y, Liu D, Shao C, Liu Q, Li X. Publicity to blue gentle stimulates the proangiogenic functionality of exosomes derived from human umbilical twine mesenchymal stem cells. Stem Cell Res Ther. 2019;10(1):358.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cao T, Chen H, Huang W, Xu S, Liu P, Zou W, Pang M, Xu Y, Bai X, Liu B, Rong L, Cui ZK, Li M. hUC-MSC-mediated restoration of subacute spinal twine harm by means of enhancing the pivotal subunits Β3 and Γ2 of the GABA(A) receptor. Theranostics. 2022;12(7):3057–78.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Lu T, Zhang J, Cai J, Xiao J, Sui X, Yuan X, Li R, Li Y, Yao J, Lv G, Chen X, Chen H, Zeng Okay, Liu Y, Chen W, Chen G, Yang Y, Zheng J, Zhang Y. Extracellular vesicles derived from mesenchymal stromal cells as nanotherapeutics for liver ischaemia-reperfusion harm by transferring mitochondria to modulate the formation of neutrophil extracellular traps. Biomaterials. 2022;284:121486.

    CAS 
    PubMed 

    Google Scholar
     

  • Galipeau J, Sensébé L. Mesenchymal stromal cells: scientific challenges and therapeutic alternatives. Cell Stem Cell. 2018;22(6):824–33.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Peng C, Trojanowski JQ, Lee VM. Protein transmission in neurodegenerative illness. Nat Critiques Neurol. 2020;16(4):199–212.

    CAS 

    Google Scholar
     

  • Deng H, Dong A, Music J, Chen X. Injectable thermosensitive hydrogel programs primarily based on useful PEG/PCL block polymer for native drug supply. J Management Launch. 2019;297:60–70.

    CAS 
    PubMed 

    Google Scholar
     

  • Pan W, Wu B, Nie C, Luo T, Music Z, Lv J, Tan Y, Liu C, Zhong M, Liao T, Wang Z, Yi G, Zhang L, Liu X, Li B, Chen J, Zheng L. NIR-II responsive nanohybrids incorporating thermosensitive hydrogel as sprayable dressing for Multidrug-Resistant-Micro organism contaminated wound administration. ACS Nano. 2023;17(12):11253–67.

    CAS 
    PubMed 

    Google Scholar
     

  • Li S, Yang C, Li J, Zhang C, Zhu L, Music Y, Guo Y, Wang R, Gan D, Shi J, Ma P, Gao F, Su H. Progress in pluronic F127 derivatives for software in wound therapeutic and restore. Int J Nanomed. 2023;18:4485–505.

    CAS 

    Google Scholar
     

  • Chao Y, Xu L, Liang C, Feng L, Xu J, Dong Z, Tian L, Yi X, Yang Okay, Liu Z. Mixed native immunostimulatory radioisotope remedy and systemic immune checkpoint Blockade imparts potent antitumour responses. Nat Biomedical Eng. 2018;2(8):611–21.

    CAS 

    Google Scholar
     

  • Lv Q, Wang Y, Tian W, Liu Y, Gu M, Jiang X, Cai Y, Huo R, Li Y, Li L, Wang X. Exosomal miR-146a-5p derived from human umbilical twine mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast harm and placental dysfunction by regulating the TRAF6/NF-κB axis. J Nanobiotechnol. 2023;21(1):419.

    CAS 

    Google Scholar
     

  • Peralta C, Jiménez-Castro MB, Gracia-Sancho J. Hepatic ischemia and reperfusion harm: results on the liver sinusoidal milieu. J Hepatol. 2013;59(5):1094–106.

    PubMed 

    Google Scholar
     

  • Jorgensen AN, Rashdan NA, Rao KNS, Delgadillo LF, Kolluru GK, Krzywanski DM, Pattillo CB, Kevil CG, Nam HW. Neurogranin expression regulates mitochondrial perform and redox steadiness in endothelial cells. Redox Biol. 2024;70:103085.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hu Z, Wang D, Gong J, Li Y, Ma Z, Luo T, Jia X, Shi Y, Music Z. MSCs ship Hypoxia-Handled mitochondria reprogramming acinar metabolism to alleviate extreme acute pancreatitis harm. Adv Sci (Weinh). 2023;10(25):e2207691.

    PubMed 

    Google Scholar
     

  • Miettinen TP, Björklund M. Mitochondrial perform and cell dimension: an allometric relationship. Traits Cell Biol. 2017;27(6):393–402.

    CAS 
    PubMed 

    Google Scholar
     

  • Xian H, Watari Okay, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M. Oxidized DNA fragments exit mitochondria through mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling. Immunity. 2022;55(8):1370–e13858.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chakradhar S. Puzzling over privilege: how the immune system protects-and fails-the testes. Nat Med. 2018;24(1):2–5.

    PubMed 

    Google Scholar
     

  • Park EH, Kim YJ, Yamabe N, Park SH, Kim HK, Jang HJ, Kim JH, Cheon GJ, Ham J, Kang KS. Stereospecific anticancer results of ginsenoside Rg3 epimers remoted from heat-processed American ginseng on human gastric most cancers cell. J Ginseng Res. 2014;38(1):22–7.

    PubMed 

    Google Scholar
     

  • Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H. Microglia-Mediated neuroinflammation: A possible goal for the therapy of cardiovascular ailments. J Inflamm Res. 2022;15:3083–94.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Ablasser A, Chen ZJ. cGAS in motion: increasing roles in immunity and irritation. Science. 2019;363(6431).

  • Gulen MF, Samson N, Keller A, Schwabenland M, Liu C, Glück S, Thacker VV, Favre L, Mangeat B, Kroese LJ, Krimpenfort P, Prinz M, Ablasser A. cGAS-STING drives ageing-related irritation and neurodegeneration. Nature. 2023;620(7973):374–80.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang HJ, Ran HF, Yin Y, Xu XG, Jiang BX, Yu SQ, Chen YJ, Ren HJ, Feng S, Zhang JF, Chen Y, Xue Q, Xu XY. Catalpol improves impaired neurovascular unit in ischemic stroke rats through enhancing VEGF-PI3K/AKT and VEGF-MEK1/2/ERK1/2 signaling. Acta Pharmacol Sin. 2022;43(7):1670–85.

    CAS 
    PubMed 

    Google Scholar
     

  • He Y, Wang H, Lin S, Chen T, Chang D, Solar Y, Wang C, Liu Y, Lu Y, Music J, Li S, Xu W, Lin Y, Zheng Y, Zhou X, Huang Q, Huang M. Superior impact of Curcumin and Resveratrol on mitigating hepatic steatosis in metabolic related fatty liver illness through the PI3K/AKT/mTOR and HIF-1/VEGF cascade. Biomed Pharmacother. 2023;165:115279.

    CAS 
    PubMed 

    Google Scholar
     

  • Yamashita M, Niisato M, Kawasaki Y, Karaman S, Robciuc MR, Shibata Y, Ishida Y, Nishio R, Masuda T, Sugai T, Ono M, Tuder RM, Alitalo Okay, Yamauchi Okay. VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung harm. Eur Respir J. 2022;59(4).

  • Meng LB, Zhang YM, Shan MJ, Qiu Y, Zhang TJ, Gong T. Pivotal micro components related to endothelial cells. Chin Med J. 2019;132(16):1965–73.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Xiong Y, Chen L, Liu P, Yu T, Lin C, Yan C, Hu Y, Zhou W, Solar Y, Panayi AC, Cao F, Xue H, Hu L, Lin Z, Xie X, Xiao X, Feng Q, Mi B, Liu G. All-in-One: multifunctional hydrogel accelerates oxidative diabetic wound therapeutic by means of Timed-Launch of exosome and fibroblast development issue, small (Weinheim an der Bergstrasse. Germany). 2022;18(1):e2104229.


    Google Scholar
     

  • Liu Okay, Gao X, Hu C, Gui Y, Gui S, Ni Q, Tao L, Jiang Z. Capsaicin ameliorates diabetic retinopathy by inhibiting poldip2-induced oxidative stress. Redox Biol. 2022;56:102460.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Fan X, Wu X, Yang F, Wang L, Ludwig Okay, Ma L, Trampuz A, Cheng C, Haag R. A Nanohook-Outfitted Bionanocatalyst for localized Close to-Infrared-Enhanced catalytic bacterial disinfection. Angew Chem Int Ed Engl. 2022;61(8):e202113833.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cohen JN, Gouirand V, Macon CE, Lowe MM, Boothby IC, Moreau JM, Gratz IK, Stoecklinger A, Weaver CT, Sharpe AH, Ricardo-Gonzalez RR, Rosenblum MD. Regulatory T cells in pores and skin mediate immune privilege of the hair follicle stem cell area of interest. Sci Immunol. 2024;9(91):eadh0152.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Li Z, Liu J, Music J, Yin Z, Zhou F, Shen H, Wang G, Su J. Multifunctional hydrogel-based engineered extracellular vesicles supply for sophisticated wound therapeutic. Theranostics. 2024;14(11):4198–217.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang Y, Lin Q, Zhang H, Wang S, Cui J, Hu Y, Liu J, Li M, Zhang Okay, Zhou F, Jing Y, Geng Z, Su J. M2 macrophage-derived exosomes promote diabetic fracture therapeutic by performing as an Immunomodulator. Bioact Mater. 2023;28:273–83.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu H, Zhang Q, Wang S, Weng W, Jing Y, Su J. Bacterial extracellular vesicles as bioactive nanocarriers for drug supply: advances and views. Bioact Mater. 2022;14:169–81.

    CAS 
    PubMed 

    Google Scholar
     

  • Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, Hei Y, Xian P, He Z, Li Z, Li N, Lengthy Q. MSC-derived exosomes defend towards oxidative stress-induced pores and skin harm through adaptive regulation of the NRF2 protection system. Biomaterials. 2020;257:120264.

    CAS 
    PubMed 

    Google Scholar
     

  • Yang KJ, Choi WJ, Chang YK, Park CW, Kim SY, Hong YA. Inhibition of Xanthine oxidase protects towards diabetic kidney illness by means of the amelioration of oxidative stress through VEGF/VEGFR Axis and NOX-FoxO3a-eNOS signaling pathway. Int J Mol Sci. 2023;24(4).

  • Related Articles

    LEAVE A REPLY

    Please enter your comment!
    Please enter your name here

    Latest Articles