McKinley KL, Longaker MT, Naik S. Rising frontiers in regenerative drugs. Science. 2023;380:796–8.
Guo S, Dipietro LA. Elements affecting wound therapeutic. J Dent Res. 2010;89:219–29.
Broughton G 2nd, Janis JE, Attinger CE. Wound therapeutic: an summary. Plast Reconstr Surg. 2006;117:e1–S.-32e-S.
Diller RB, Tabor AJ. The function of the extracellular matrix (ECM) in wound therapeutic: A evaluate. Biomimetics; 2022. p. 7.
Gonzalez AC, Costa TF, Andrade ZA, Medrado AR. Wound therapeutic – A literature evaluate. Bras Dermatol. 2016;91:614–20.
Tsioris Ok, Raja WK, Pritchard EM, Panilaitis B, Kaplan DL, Omenetto FG. Fabrication of silk microneedles for Managed-Launch drug supply. Adv Funct Mater. 2012;22:330–5.
Khalil H, Cullen M, Chambers H, McGrail M. Medicines affecting therapeutic: an evidence-based evaluation. Int Wound J. 2017;14:1340–5.
Sobhani A, Khanlarkhani N, Baazm M, Mohammadzadeh F, Najafi A, Mehdinejadiani S. Sargolzaei Aval F: multipotent stem cell and present software. Acta Med Iran. 2017;55:6–23.
Shukla SK, Sharma AK, Gupta V, Yashavarddhan MH. Pharmacological management of irritation in wound therapeutic. J Tissue Viability. 2019;28:218–22.
Ankrum JA, Ong JF, Karp JM. Mesenchymal stem cells: immune evasive, not immune privileged. Nat Biotechnol. 2014;32:252–60.
Gallina C, Capeloa T, Saviozzi S, Accomasso L, Catalano F, Tullio F, Martra G, Penna C, Pagliaro P, Turinetto V, Giachino C. Human mesenchymal stem cells labelled with dye-loaded amorphous silica nanoparticles: long-term biosafety, stemness preservation and traceability within the beating coronary heart. J Nanobiotechnol. 2015;13:77.
Zhou T, Yuan Z, Weng J, Pei D, Du X, He C, Lai P. Challenges and advances in medical functions of mesenchymal stromal cells. J Hematol Oncol. 2021;14:24.
Keshtkar S, Azarpira N, Ghahremani MH. Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative drugs. Stem Cell Res Ther. 2018;9:63.
Li P, Kaslan M, Lee SH, Yao J, Gao Z. Progress in exosome isolation strategies. Theranostics. 2017;7:789–804.
Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R, et al. Reassessment Exosome Composition Cell. 2019;177:428–e445418.
van Niel G, D’Angelo G, Raposo G. Shedding gentle on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19:213–28.
Huotari J, Helenius A. Endosome maturation. EMBO J. 2011;30:3481–500.
Kalluri R, LeBleu VS. The biology, operate, and biomedical functions of exosomes. Science 2020, 367.
Ni Z, Zhou S, Li S, Kuang L, Chen H, Luo X, Ouyang J, He M, Du X, Chen L. Exosomes: roles and therapeutic potential in osteoarthritis. Bone Res. 2020;8:25.
Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles 2014, 3.
Yang J, Liu XX, Fan H, Tang Q, Shou ZX, Zuo DM, Zou Z, Xu M, Chen QY, Peng Y, et al. Extracellular vesicles derived from bone marrow mesenchymal stem cells shield towards experimental colitis by way of attenuating Colon irritation, oxidative stress and apoptosis. PLoS ONE. 2015;10:e0140551.
Monguio-Tortajada M, Roura S, Galvez-Monton C, Pujal JM, Aran G, Sanjurjo L, Franquesa M, Sarrias MR, Bayes-Genis A, Borras FE. Nanosized UCMSC-derived extracellular vesicles however not conditioned medium solely inhibit the inflammatory response of stimulated T cells: implications for nanomedicine. Theranostics. 2017;7:270–84.
Hu P, Yang Q, Wang Q, Shi C, Wang D, Armato U, Pra ID, Chiarini A. Mesenchymal stromal cells-exosomes: a promising cell-free therapeutic software for wound therapeutic and cutaneous regeneration. Burns Trauma. 2019;7:38.
Yeo RWY, Lai RC, Tan KH, Lim SK. Exosome: A novel and safer therapeutic refinement of mesenchymal stem cell. Exosomes Microvesicles. 2013;1:7.
Popowski KD, Moatti A, Scull G, Silkstone D, Lutz H, Lopez de Juan Abad B, George A, Belcher E, Zhu D, Mei X, et al. Inhalable dry powder mRNA vaccines based mostly on extracellular vesicles. Matter. 2022;5:2960–74.
Nagelkerke A, Ojansivu M, van der Koog L, Whittaker TE, Cunnane EM, Silva AM, Dekker N, Stevens MM. Extracellular vesicles for tissue restore and regeneration: proof, challenges and alternatives. Adv Drug Deliv Rev. 2021;175:113775.
Bunggulawa EJ, Wang W, Yin T, Wang N, Durkan C, Wang Y, Wang G. Current developments in the usage of exosomes as drug supply techniques. J Nanobiotechnol. 2018;16:1–13.
Kim HY, Kwon S, Um W, Shin S, Kim CH, Park JH, Kim BS. Useful extracellular vesicles for regenerative drugs. Small. 2022;18:e2106569.
Wan JJ, Yi J, Wang FY, Zhang C, Dai AG. Expression and regulation of HIF-1a in hypoxic pulmonary hypertension: give attention to pathological mechanism and Pharmacological therapy. Int J Med Sci. 2024;21:45–60.
Zhang B, Tian X, Qu Z, Hao J, Zhang W. Hypoxia-Preconditioned extracellular vesicles from mesenchymal stem cells enhance cartilage restore in osteoarthritis. Membr (Basel) 2022, 12.
Tian J, Chen W, Xiong Y, Li Q, Kong S, Li M, Pang C, Qiu Y, Xu Z, Gong Q, Wei X. Small extracellular vesicles derived from hypoxic preconditioned dental pulp stem cells ameliorate inflammatory osteolysis by modulating macrophage polarization and osteoclastogenesis. Bioact Mater. 2023;22:326–42.
Wang R, Xu B, Xu H. TGF-beta1 promoted chondrocyte proliferation by regulating Sp1 by way of MSC-exosomes derived miR-135b. Cell Cycle. 2018;17:2756–65.
Nakao Y, Fukuda T, Zhang Q, Sanui T, Shinjo T, Kou X, Chen C, Liu D, Watanabe Y, Hayashi C, et al. Exosomes from TNF-alpha-treated human gingiva-derived MSCs improve M2 macrophage polarization and inhibit periodontal bone loss. Acta Biomater. 2021;122:306–24.
Riazifar M, Mohammadi MR, Pone EJ, Yeri A, Lasser C, Segaliny AI, McIntyre LL, Shelke GV, Hutchins E, Hamamoto A, et al. Stem Cell-Derived exosomes as nanotherapeutics for autoimmune and neurodegenerative issues. ACS Nano. 2019;13:6670–88.
Huang J, Cao H, Cui B, Ma X, Gao L, Yu C, Shen F, Yang X, Liu N, Qiu A, et al. Mesenchymal stem Cells-Derived exosomes ameliorate ischemia/reperfusion induced acute kidney harm in a Porcine mannequin. Entrance Cell Dev Biol. 2022;10:899869.
Ren Q, Xu Y, Xu L, Lu Y, Zheng Y. Hypoxic bone marrow mesenchymal stem cell-derived Exosomal LncRNA XIST attenuates lipopolysaccharide-induced acute lung harm by way of the miR-455-3p/Claudin-4 axis. Int Immunopharmacol. 2023;125:111066.
Shen Ok, Duan A, Cheng J, Yuan T, Zhou J, Track H, Chen Z, Wan B, Liu J, Zhang X, et al. Exosomes derived from hypoxia preconditioned mesenchymal stem cells laden in a silk hydrogel promote cartilage regeneration by way of the miR-205-5p/PTEN/AKT pathway. Acta Biomater. 2022;143:173–88.
Roberts S, Colombier P, Sowman A, Mennan C, Rolfing JH, Guicheux J, Edwards JR. Ageing within the musculoskeletal system. Acta Orthop. 2016;87:15–25.
McPhee JS, French DP, Jackson D, Nazroo J, Pendleton N, Degens H. Bodily exercise in older age: views for wholesome ageing and frailty. Biogerontology. 2016;17:567–80.
Block JA, Cherny D. Administration of knee osteoarthritis: what internists must know. Med Clin North Am. 2021;105:367–85.
Cobelli NJ, Leong DJ, Solar HB. Exosomes: biology, therapeutic potential, and rising function in musculoskeletal restore and regeneration. Ann N Y Acad Sci. 2017;1410:57–67.
Zhang J, Rong Y, Luo C, Cui W. Bone marrow mesenchymal stem cell-derived exosomes stop osteoarthritis by regulating synovial macrophage polarization. Ageing. 2020;12:25138–52.
Lu Z, Chen Y, Dunstan C, Roohani-Esfahani S, Zreiqat H. Priming adipose stem cells with tumor necrosis Issue-Alpha preconditioning potentiates their exosome efficacy for bone regeneration. Tissue Eng Half A. 2017;23:1212–20.
Duan A, Shen Ok, Li B, Li C, Zhou H, Kong R, Shao Y, Qin J, Yuan T, Ji J, et al. Extracellular vesicles derived from LPS-preconditioned human synovial mesenchymal stem cells inhibit extracellular matrix degradation and forestall osteoarthritis of the knee in a mouse mannequin. Stem Cell Res Ther. 2021;12:427.
Shi W, Guo S, Liu L, Liu Q, Huo F, Ding Y, Tian W. Small extracellular vesicles from Lipopolysaccharide-Preconditioned dental follicle cells promote periodontal regeneration in an inflammatory microenvironment. ACS Biomater Sci Eng. 2020;6:5797–810.
Chen WJ, Xie J, Lin X, Ou MH, Zhou J, Wei XL, Chen WX. The function of small extracellular vesicles derived from Lipopolysaccharide-preconditioned human dental pulp stem cells in dental pulp regeneration. J Endod. 2021;47:961–9.
Liao Z, Li S, Lu S, Liu H, Li G, Ma L, Luo R, Ke W, Wang B, Xiang Q, et al. Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles launch and optimizes therapeutic efficacy in intervertebral disc degeneration. Biomaterials. 2021;274:120850.
Sribnick EA, Popovich PG, Corridor MW. Central nervous system injury-induced immune suppression. Neurosurg Focus. 2022;52:E10.
Gratpain V, Mwema A, Labrak Y, Muccioli GG, van Pesch V, des, Rieux A. Extracellular vesicles for the therapy of central nervous system illnesses. Adv Drug Deliv Rev 2021, 174:535–552.
Badyra B, Sulkowski M, Milczarek O, Majka M. Mesenchymal stem cells as a multimodal therapy for nervous system illnesses. Stem Cells Transl Med. 2020;9:1174–89.
Lu Y, Zhou Y, Zhang R, Wen L, Wu Ok, Li Y, Yao Y, Duan R, Jia Y. Bone mesenchymal stem Cell-Derived extracellular vesicles promote restoration following spinal twine harm by way of enchancment of the integrity of the Blood-Spinal twine barrier. Entrance Neurosci. 2019;13:209.
Katsuda T, Tsuchiya R, Kosaka N, Yoshioka Y, Takagaki Ok, Oki Ok, Takeshita F, Sakai Y, Kuroda M, Ochiya T. Human adipose tissue-derived mesenchymal stem cells secrete practical neprilysin-bound exosomes. Sci Rep. 2013;3:1197.
Vilaca-Faria H, Salgado AJ, Teixeira FG. Mesenchymal Stem Cells-derived Exosomes: A New Potential Therapeutic Technique for Parkinson’s Illness? Cells 2019, 8.
Baharlooi H, Salehi Z, Minbashi Moeini M, Rezaei N, Azimi M. Immunomodulatory potential of human mesenchymal stem cells and their exosomes on a number of sclerosis. Adv Pharm Bull. 2022;12:389–97.
Liu W, Rong Y, Wang J, Zhou Z, Ge X, Ji C, Jiang D, Gong F, Li L, Chen J, et al. Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells restore traumatic spinal twine harm by shifting microglial M1/M2 polarization. J Neuroinflammation. 2020;17:47.
Cui GH, Wu J, Mou FF, Xie WH, Wang FB, Wang QL, Fang J, Xu YW, Dong YR, Liu JR, Guo HD. Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice. FASEB J. 2018;32:654–68.
Losurdo M, Pedrazzoli M, D’Agostino C, Elia CA, Massenzio F, Lonati E, Mauri M, Rizzi L, Molteni L, Bresciani E, et al. Intranasal supply of mesenchymal stem cell-derived extracellular vesicles exerts Immunomodulatory and neuroprotective results in a 3xTg mannequin of Alzheimer’s illness. Stem Cells Transl Med. 2020;9:1068–84.
Zhang G, Zhu Z, Wang H, Yu Y, Chen W, Waqas A, Wang Y, Chen L. Exosomes derived from human neural stem cells stimulated by interferon gamma enhance therapeutic skill in ischemic stroke mannequin. J Adv Res. 2020;24:435–45.
Liu W, Tang P, Wang J, Ye W, Ge X, Rong Y, Ji C, Wang Z, Bai J, Fan J, et al. Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 restore traumatic spinal twine harm by stabilizing NRF2. J Pineal Res. 2021;71:e12769.
Basil MC, Katzen J, Engler AE, Guo M, Herriges MJ, Kathiriya JJ, Windmueller R, Ysasi AB, Zacharias WJ, Chapman HA, et al. The mobile and physiological foundation for lung restore and regeneration: previous, current, and future. Cell Stem Cell. 2020;26:482–502.
Chuquimia OD, Petursdottir DH, Rahman MJ, Hartl Ok, Singh M, Fernández C. The function of alveolar epithelial cells in initiating and shaping pulmonary immune responses: communication between innate and adaptive immune techniques. PLoS ONE. 2012;7:e32125.
Bos LDJ, Ware LB. Acute respiratory misery syndrome: causes, pathophysiology, and phenotypes. Lancet. 2022;400:1145–56.
Johnson ER, Matthay MA. Acute lung harm: epidemiology, pathogenesis, and therapy. J Aerosol Med Pulm Drug Deliv. 2010;23:243–52.
Hu Q, Zhang S, Yang Y, Yao JQ, Tang WF, Lyon CJ, Hu TY, Wan MH. Extracellular vesicles within the pathogenesis and therapy of acute lung harm. Navy Med Res 2022, 9.
Krasnodembskaya A, Samarani G, Track Y, Zhuo H, Su X, Lee JW, Gupta N, Petrini M, Matthay MA. Human mesenchymal stem cells cut back mortality and bacteremia in gram-negative sepsis in mice partly by enhancing the phagocytic exercise of blood monocytes. Am J Physiol Lung Cell Mol Physiol. 2012;302:L1003–1013.
Shen Ok, Wang X, Wang Y, Jia Y, Zhang Y, Wang Ok, Luo L, Cai W, Li J, Li S, et al. miR-125b-5p in adipose derived stem cells exosome alleviates pulmonary microvascular endothelial cells ferroptosis by way of Keap1/Nrf2/GPX4 in sepsis lung harm. Redox Biol. 2023;62:102655.
Silva JD, Lopes-Pacheco M, de Castro LL, Kitoko JZ, Trivelin SA, Amorim NR, Capelozzi VL, Morales MM, Gutfilen B, de Souza SAL, et al. Eicosapentaenoic acid potentiates the therapeutic results of adipose tissue-derived mesenchymal stromal cells on lung and distal organ harm in experimental sepsis. Stem Cell Res Ther. 2019;10:264.
Abazari M, Ghaffari A, Rashidzadeh H, Badeleh SM, Maleki Y. A scientific evaluate on classification, identification, and therapeutic technique of burn wound therapeutic. Int J Low Extrem Wounds. 2022;21:18–30.
Eming SA, Krieg T, Davidson JM. Irritation in wound restore: molecular and mobile mechanisms. J Make investments Dermatol. 2007;127:514–25.
Han G, Ceilley R. Continual wound therapeutic: A evaluate of present administration and coverings. Adv Ther. 2017;34:599–610.
Dai C, Shih S, Khachemoune A. Pores and skin substitutes for acute and continual wound therapeutic: an up to date evaluate. J Dermatolog Deal with. 2020;31:639–48.
Wu P, Zhang B, Shi H, Qian H, Xu W. MSC-exosome: A novel cell-free remedy for cutaneous regeneration. Cytotherapy. 2018;20:291–301.
Guo SC, Tao SC, Yin WJ, Qi X, Yuan T, Zhang CQ. Exosomes derived from platelet-rich plasma promote the re-epithelization of continual cutaneous wounds by way of activation of YAP in a diabetic rat mannequin. Theranostics. 2017;7:81–96.
Wang Y, Zhang Y, Li T, Shen Ok, Wang KJ, Tian C, Hu D. Adipose mesenchymal stem cell derived exosomes promote keratinocytes and fibroblasts embedded in Collagen/Platelet-Wealthy plasma scaffold and speed up wound therapeutic. Adv Mater 2023:e2303642.
Han Y, Ren J, Bai Y, Pei X, Han Y. Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells improve angiogenesis by way of VEGF/VEGF-R. Int J Biochem Cell Biol. 2019;109:59–68.
Ti D, Hao H, Tong C, Liu J, Dong L, Zheng J, Zhao Y, Liu H, Fu X, Han W. LPS-preconditioned mesenchymal stromal cells modify macrophage polarization for decision of continual irritation by way of exosome-shuttled let-7b. J Transl Med. 2015;13:308.
Sung DK, Chang YS, Sung SI, Ahn SY, Park WS. Thrombin preconditioning of extracellular vesicles derived from mesenchymal stem cells accelerates cutaneous wound therapeutic by boosting their biogenesis and enriching cargo content material. J Clin Med 2019, 8.
Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, et al. International burden of cardiovascular illnesses and threat components, 1990–2019: replace from the GBD 2019 examine. J Am Coll Cardiol. 2020;76:2982–3021.
Shao C, Wang J, Tian J, Tang YD. Coronary artery illness: from mechanism to medical apply. Adv Exp Med Biol. 2020;1177:1–36.
Lu L, Liu M, Solar R, Zheng Y, Zhang P. Myocardial infarction: signs and coverings. Cell Biochem Biophys. 2015;72:865–7.
Zhang Q, Wang L, Wang S, Cheng H, Xu L, Pei G, Wang Y, Fu C, Jiang Y, He C, Wei Q. Signaling pathways and focused remedy for myocardial infarction. Sign Transduct Goal Ther. 2022;7:78.
Zou L, Ma X, Lin S, Wu B, Chen Y, Peng C. Bone marrow mesenchymal stem cell-derived exosomes shield towards myocardial infarction by selling autophagy. Exp Ther Med. 2019;18:2574–82.
Ma X, Wang J, Li J, Ma C, Chen S, Lei W, Yang Y, Liu S, Bihl J, Chen C. Loading MiR-210 in endothelial progenitor cells derived exosomes boosts their helpful results on Hypoxia/Reoxygeneation-Injured human endothelial cells by way of defending mitochondrial operate. Cell Physiol Biochem. 2018;46:664–75.
Zhu LP, Tian T, Wang JY, He JN, Chen T, Pan M, Xu L, Zhang HX, Qiu XT, Li CC, et al. Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac restore by way of miR-125b-mediated prevention of cell demise in myocardial infarction. Theranostics. 2018;8:6163–77.
Mao C, Li D, Zhou E, Gao E, Zhang T, Solar S, Gao L, Fan Y, Wang C. Extracellular vesicles from anoxia preconditioned mesenchymal stem cells alleviate myocardial ischemia/reperfusion harm. Ageing. 2021;13:6156–70.
Xu R, Zhang F, Chai R, Zhou W, Hu M, Liu B, Chen X, Liu M, Xu Q, Liu N, Liu S. Exosomes derived from pro-inflammatory bone marrow-derived mesenchymal stem cells cut back irritation and myocardial harm by way of mediating macrophage polarization. J Cell Mol Med. 2019;23:7617–31.
Oliveira F, Assreuy J, Sordi R. The function of nitric oxide in sepsis-associated kidney harm. Biosci Rep 2022, 42.
Webster AC, Nagler EV, Morton RL, Masson P. Continual Kidney Illness Lancet. 2017;389:1238–52.
Yeo WS, Zhang YC. Bioengineering in renal transplantation: technological advances and novel choices. Pediatr Nephrol. 2018;33:1105–11.
Fisher M, Golestaneh L, Allon M, Abreo Ok, Mokrzycki MH. Prevention of bloodstream infections in sufferers present process Hemodialysis. Clin J Am Soc Nephrol. 2020;15:132–51.
Nassar W, El-Ansary M, Sabry D, Mostafa MA, Fayad T, Kotb E, Temraz M, Saad AN, Essa W, Adel H. Umbilical twine mesenchymal stem cells derived extracellular vesicles can safely ameliorate the development of continual kidney illnesses. Biomater Res. 2016;20:21.
Gao Z, Zhang C, Peng F, Chen Q, Zhao Y, Chen L, Wang X, Chen X. Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation. Stem Cell Res Ther. 2022;13:191.
Alzahrani FA. Melatonin improves therapeutic potential of mesenchymal stem cells-derived exosomes towards renal ischemia-reperfusion harm in rats. Am J Transl Res. 2019;11:2887–907.
Williams PR, Benowitz LI, Goldberg JL, He Z. Axon regeneration within the mammalian optic nerve. Annu Rev Vis Sci. 2020;6:195–213.
Storgaard L, Tran TL, Freiberg JC, Hauser AS, Kolko M. Glaucoma medical analysis: developments in therapy methods and drug improvement. Entrance Med (Lausanne). 2021;8:733080.
Coulon SJ, Schuman JS, Du Y, Bahrani Fard MR, Ethier CR, Stamer WD. A novel glaucoma strategy: stem cell regeneration of the trabecular meshwork. Prog Retin Eye Res. 2022;90:101063.
Oveili E, Vafaei S, Bazavar H, Eslami Y, Mamaghanizadeh E, Yasamineh S, Gholizadeh O. The potential use of mesenchymal stem cells-derived exosomes as MicroRNAs supply techniques in numerous illnesses. Cell Commun Sign. 2023;21:20.
Mead B, Chamling X, Zack DJ, Ahmed Z, Tomarev S. TNFalpha-Mediated priming of mesenchymal stem cells enhances their neuroprotective impact on retinal ganglion cells. Make investments Ophthalmol Vis Sci. 2020;61:6.
Johnson RW, Sowder ME, Giaccia AJ. Hypoxia and bone metastatic illness. Curr Osteoporos Rep. 2017;15:231–8.
Chen S, Solar F, Qian H, Xu W, Jiang J. Preconditioning and Engineering Methods for Bettering the Efficacy of Mesenchymal Stem Cell-Derived Exosomes in Cell-Free Remedy. Stem Cells Int 2022, 2022:1779346.
Ma T, Grayson WL, Frohlich M, Vunjak-Novakovic G. Hypoxia and stem cell-based engineering of mesenchymal tissues. Biotechnol Prog. 2009;25:32–42.
Lavrentieva A, Majore I, Kasper C, Hass R. Results of hypoxic tradition situations on umbilical cord-derived human mesenchymal stem cells. Cell Commun Sign. 2010;8:18.
Xu W, Xu R, Li Z, Wang Y, Hu R. Hypoxia modifications chemotaxis behaviour of mesenchymal stem cells by way of HIF-1alpha signalling. J Cell Mol Med. 2019;23:1899–907.
Estrada JC, Albo C, Benguria A, Dopazo A, Lopez-Romero P, Carrera-Quintanar L, Roche E, Clemente EP, Enriquez JA, Bernad A, Samper E. Tradition of human mesenchymal stem cells at low oxygen rigidity improves progress and genetic stability by activating Glycolysis. Cell Dying Differ. 2012;19:743–55.
Silk AW, Margolin Ok. Cytokine remedy. Hematol Oncol Clin North Am. 2019;33:261–74.
Xin P, Xu X, Deng C, Liu S, Wang Y, Zhou X, Ma H, Wei D, Solar S. The function of JAK/STAT signaling pathway and its inhibitors in illnesses. Int Immunopharmacol. 2020;80:106210.
Liu T, Zhang L, Joo D, Solar S-C. NF-κB signaling in irritation. Sign Transduct Goal Remedy. 2017;2:17023.
Xue C, Li G, Lu J, Li L. Crosstalk between circrnas and the PI3K/AKT signaling pathway in most cancers development. Sign Transduct Goal Ther. 2021;6:400.
Nabavi SM, Nabavi SF, Sureda A, Xiao J, Dehpour AR, Shirooie S, Silva AS, Baldi A, Khan H, Daglia M. Anti-inflammatory results of melatonin: A mechanistic evaluate. Crit Rev Meals Sci Nutr. 2019;59:S4–16.
Liu R, AbdulHameed MDM, Wallqvist A. Molecular Construction-Based mostly Giant-Scale prediction of Chemical-Induced gene expression modifications. J Chem Inf Mannequin. 2017;57:2194–202.
Liu M, Hu S, Yan N, Popowski KD, Cheng Ok. Inhalable extracellular vesicle supply of IL-12 mRNA to deal with lung most cancers and promote systemic immunity. Nat Nanotechnol. 2024;19:565–75.
Bui VD, Son S, Xavier W, Nguyen VQ, Jung JM, Lee J, Shin S, Um W, An JY, Kim CH, et al. Dissolving microneedles for long-term storage and transdermal supply of extracellular vesicles. Biomaterials. 2022;287:121644.
Bui VD, Jeon J, Duong VH, Shin S, Lee J, Ghahari F, Kim CH, Jo YJ, Jung WK, Um W, Park JH. Chondroitin sulfate-based microneedles for transdermal supply of stem cell-derived extracellular vesicles to deal with rheumatoid arthritis. J Management Launch. 2024;375:105–15.