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Hypoxic glioma-derived exosomal miR-25-3p promotes macrophage M2 polarization by activating the PI3K-AKT-mTOR signaling pathway | Journal of Nanobiotechnology


  • Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, et al. Malignant astrocytic glioma: genetics, biology, and paths to therapy. Genes Dev. 2007;21(21):2683–710.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger Okay, Brandes AA, Marosi C, Bogdahn U, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987–96.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Stupp R, Taillibert S, Kanner A, Learn W, Steinberg D, Lhermitte B, Toms S, Idbaih A, Ahluwalia MS, Fink Okay, et al. Impact of Tumor-Treating Fields Plus upkeep temozolomide vs upkeep temozolomide alone on survival in sufferers with glioblastoma: a Randomized Scientific Trial. JAMA. 2017;318(23):2306–16.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Charles N, Holland EC. The perivascular area of interest microenvironment in mind tumor development. Cell Cycle (Georgetown Tex). 2010;9(15):3012–21.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE, et al. Hypoxia-inducible components regulate tumorigenic capability of glioma stem cells. Most cancers Cell. 2009;15(6):501–13.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hao NB, Lü MH, Fan YH, Cao YL, Zhang ZR, Yang SM. Macrophages in tumor microenvironments and the development of tumors. Scientific & developmental immunology 2012, 2012:948098.

  • Quail DF, Joyce JA. Microenvironmental regulation of tumor development and metastasis. Nat Med. 2013;19(11):1423–37.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Dello Russo C, Cappoli N, Coletta I, Mezzogori D, Paciello F, Pozzoli G, Navarra P, Battaglia A. The human microglial HMC3 cell line: the place will we stand? A scientific literature overview. J Neuroinflamm. 2018;15(1):259.

    Article 

    Google Scholar
     

  • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in numerous types of macrophage activation and polarization. Traits Immunol. 2004;25(12):677–86.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Gordon S, Taylor PR. Monocyte and macrophage heterogeneity. Nat Rev Immunol. 2005;5(12):953–64.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Ye XZ, Xu SL, Xin YH, Yu SC, Ping YF, Chen L, Xiao HL, Wang B, Yi L, Wang QL, et al. Tumor-associated microglia/macrophages improve the invasion of glioma stem-like cells by way of TGF-β1 signaling pathway. J Immunol. 2012;189(1):444–53.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Guo X, Zhao Y, Yan H, Yang Y, Shen S, Dai X, Ji X, Ji F, Gong XG, Li L, et al. Single tumor-initiating cells evade immune clearance by recruiting kind II macrophages. Genes Dev. 2017;31(3):247–59.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhu C, Mustafa D, Zheng PP, van der Weiden M, Sacchetti A, Brandt M, Chrifi I, Tempel D, Leenen PJM, Duncker DJ, et al. Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor development. Neuro Oncol. 2017;19(5):648–59.

    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Cao J, Dong R, Jiang L, Gong Y, Yuan M, You J, Meng W, Chen Z, Zhang N, Weng Q, et al. LncRNA-MM2P recognized as a modulator of macrophage M2 polarization. Most cancers Immunol Res. 2019;7(2):292–305.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Kalluri R, LeBleu VS. The biology, perform, and biomedical purposes of exosomes. Science (New York, NY) 2020, 367(6478).

  • Tkach M, Théry C. Communication by Extracellular vesicles: the place we’re and the place we have to go. Cell. 2016;164(6):1226–32.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D. Extracellular vesicles in Most cancers: cell-to-cell mediators of Metastasis. Most cancers Cell. 2016;30(6):836–48.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R, et al. Reassessment of Exosome Composition. Cell. 2019;177(2):428–e445418.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Tian W, Lei N, Zhou J, Chen M, Guo R, Qin B, Li Y, Chang L. Extracellular vesicles in ovarian most cancers chemoresistance, metastasis, and immune evasion. Cell Loss of life Dis. 2022;13(1):64.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Valadi H, Ekström Okay, Bossios A, Sjöstrand M, Lee JJ, Lötvall JO. Exosome-mediated switch of mRNAs and microRNAs is a novel mechanism of genetic change between cells. Nat Cell Biol. 2007;9(6):654–9.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li L, Li C, Wang S, Wang Z, Jiang J, Wang W, Li X, Chen J, Liu Okay, Li C, et al. Exosomes derived from hypoxic oral squamous cell carcinoma cells ship miR-21 to Normoxic Cells to Elicit a Prometastatic phenotype. Most cancers Res. 2016;76(7):1770–80.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Qiu S, Xie L, Lu C, Gu C, Xia Y, Lv J, Xuan Z, Fang L, Yang J, Zhang L, et al. Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis. J Exp Clin Most cancers Res. 2022;41(1):296.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liang Y, Duan L, Lu J, Xia J. Engineering exosomes for focused drug supply. Theranostics. 2021;11(7):3183–95.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Kimiz-Gebologlu I, Oncel SS. Exosomes: large-scale manufacturing, isolation, drug loading effectivity, and biodistribution and uptake. J Management Launch. 2022;347:533–43.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Bartel DP. Metazoan MicroRNAs. Cell. 2018;173(1):20–51.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Friedman RC, Farh KK, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92–105.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Iorio MV, Croce CM. MicroRNA dysregulation in most cancers: diagnostics, monitoring and therapeutics. A complete overview. EMBO Mol Med. 2012;4(3):143–59.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shah MY, Ferrajoli A, Sood AK, Lopez-Berestein G, Calin GA. microRNA therapeutics in Most cancers – An Rising Idea. EBioMedicine. 2016;12:34–42.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Rupaimoole R, Slack FJ. MicroRNA therapeutics: in the direction of a brand new period for the administration of most cancers and different illnesses. Nat Rev Drug Discov. 2017;16(3):203–22.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang L, Liao Y, Tang L. MicroRNA-34 household: a possible tumor suppressor and therapeutic candidate in most cancers. J Exp Clin Most cancers Res. 2019;38(1):53.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao S, Mi Y, Guan B, Zheng B, Wei P, Gu Y, Zhang Z, Cai S, Xu Y, Li X, et al. Tumor-derived exosomal miR-934 induces macrophage M2 polarization to advertise liver metastasis of colorectal most cancers. J Hematol Oncol. 2020;13(1):156.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yin Y, Liu B, Cao Y, Yao S, Liu Y, Jin G, Qin Y, Chen Y, Cui Okay, Zhou L, et al. Colorectal Most cancers-derived small extracellular vesicles promote Tumor Immune Evasion by upregulating PD-L1 expression in Tumor-Related macrophages. Adv Sci (Weinh). 2022;9(9):2102620.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Deng C, Huo M, Chu H, Zhuang X, Deng G, Li W, Wei H, Zeng L, He Y, Liu H, et al. Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to advertise gastric most cancers development. Mol Most cancers. 2024;23(1):49.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang X, Luo G, Zhang Okay, Cao J, Huang C, Jiang T, Liu B, Su L, Qiu Z. Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization by way of PTEN/PI3Kγ to advertise pancreatic Most cancers metastasis. Most cancers Res. 2018;78(16):4586–98.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Wang D, Wang X, Si M, Yang J, Solar S, Wu H, Cui S, Qu X, Yu X. Exosome-encapsulated miRNAs contribute to CXCL12/CXCR4-induced liver metastasis of colorectal most cancers by enhancing M2 polarization of macrophages. Most cancers Lett. 2020;474:36–52.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hu Y, Yuan M, Cheng L, Xu L, Wang G. Extracellular vesicle-encapsulated mir-25-3p promotes epithelial-mesenchymal transition and migration of endometrial epithelial cells by inducing macrophage polarization. Mol Hum Reprod 2024, 30(4): 1-17.

  • Peng G, Yuan X, Yuan J, Liu Q, Dai M, Shen C, Ma J, Liao Y, Jiang W. miR-25 promotes glioblastoma cell proliferation and invasion by instantly focusing on NEFL. Mol Cell Biochem. 2015;409(1–2):103–11.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang J, Gong X, Tian Okay, Chen D, Solar J, Wang G, Guo M. miR-25 promotes glioma cell proliferation by focusing on CDKN1C. Biomed Pharmacotherapy = Biomedecine Pharmacotherapie. 2015;71:7–14.

    Article 
    CAS 

    Google Scholar
     

  • Malzkorn B, Wolter M, Liesenberg F, Grzendowski M, Stühler Okay, Meyer HE, Reifenberger G. Identification and purposeful characterization of microRNAs concerned within the malignant development of gliomas. Mind Pathol. 2010;20(3):539–50.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Yang Z, Gong W, Zhang T, Gao H. Molecular options of Glioma decided and validated utilizing Mixed TCGA and GTEx Knowledge analyses. Entrance Oncol. 2021;11:729137.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi L, Cao Y, Yuan W, Guo J, Solar G. Exosomal circRNA BTG2 derived from RBP-J overexpressed-macrophages inhibits glioma development by way of miR-25-3p/PTEN. Cell Loss of life Dis. 2022;13(5):506.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Wang J, Li T, Wang B. Exosomal switch of miR–25–3p promotes the proliferation and temozolomide resistance of glioblastoma cells by focusing on FBXW7. Int J Oncol 2021, 59(2): 1-15.

  • Tankov S, Petrovic M, Lecoultre M, Espinoza F, El-Harane N, Bes V, Chliate S, Bedoya DM, Jordan O, Borchard G, et al. Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING exercise in macrophages. Cell Communication Signaling: CCS. 2024;22(1):144.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu T, Zhang X, Du L, Wang Y, Liu X, Tian H, Wang L, Li P, Zhao Y, Duan W, et al. Exosome-transmitted mir-128-3p improve chemosensitivity of oxaliplatin-resistant colorectal most cancers. Mol Most cancers. 2019;18(1):43.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Qian M, Wang S, Guo X, Wang J, Zhang Z, Qiu W, Gao X, Chen Z, Xu J, Zhao R, et al. Hypoxic glioma-derived exosomes ship microRNA-1246 to induce M2 macrophage polarization by focusing on TERF2IP by way of the STAT3 and NF-κB pathways. Oncogene. 2020;39(2):428–42.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Hoshino A, Kim HS, Bojmar L, Gyan KE, Cioffi M, Hernandez J, Zambirinis CP, Rodrigues G, Molina H, Heissel S, et al. Extracellular vesicle and particle biomarkers outline a number of human cancers. Cell. 2020;182(4):1044–e10611018.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gardiner C, Di Vizio D, Sahoo S, Théry C, Witwer KW, Wauben M, Hill AF. Strategies used for the isolation and characterization of extracellular vesicles: outcomes of a worldwide survey. J Extracell Vesicles. 2016;5:32945.

    Article 
    PubMed 

    Google Scholar
     

  • Yang W, Zhang J, Xu B, He Y, Liu W, Li J, Zhang S, Lin X, Su D, Wu T, et al. HucMSC-Derived exosomes mitigate the age-related retardation of fertility in feminine mice. Mol Remedy: J Am Soc Gene Remedy. 2020;28(4):1200–13.

    Article 
    CAS 

    Google Scholar
     

  • Vujić T, Schvartz D, Iliuk A, Sanchez JC. Ubiquinone metabolism and transcription HIF-1 targets pathway are toxicity signature pathways Current in Extracellular vesicles of paraquat-exposed human mind microvascular endothelial cells. Int J Mol Sci 2021, 22(10): 1-12.

  • Zeng Z, Li Y, Pan Y, Lan X, Tune F, Solar J, Zhou Okay, Liu X, Ren X, Wang F, et al. Most cancers-derived exosomal mir-25-3p promotes pre-metastatic area of interest formation by inducing vascular permeability and angiogenesis. Nat Commun. 2018;9(1):5395.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhao SJ, Kong FQ, Jie J, Li Q, Liu H, Xu AD, Yang YQ, Jiang B, Wang DD, Zhou ZQ, et al. Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway. Theranostics. 2020;10(1):17–35.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW, et al. Round RNA ANAPC7 inhibits Tumor Development and muscle losing by way of PHLPP2-AKT-TGF-β Signaling Axis in Pancreatic Most cancers. Gastroenterology. 2022;162(7):2004–17. e2002.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Quail DF, Joyce JA. The Microenvironmental Panorama of Mind tumors. Most cancers Cell. 2017;31(3):326–41.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hara T, Chanoch-Myers R, Mathewson ND, Myskiw C, Atta L, Bussema L, Eichhorn SW, Greenwald AC, Kinker GS, Rodman C, et al. Interactions between most cancers cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Most cancers Cell. 2021;39(6):779–e792711.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors Okay, Joyce JA, Homicsko Okay, Hanahan D. Most cancers cell autophagy, reprogrammed macrophages, and reworked vasculature in glioblastoma triggers tumor immunity. Most cancers Cell. 2022;40(10):1111–e11271119.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yeo AT, Rawal S, Delcuze B, Christofides A, Atayde A, Strauss L, Balaj L, Rogers VA, Uhlmann EJ, Varma H, et al. Single-cell RNA sequencing reveals evolution of immune panorama throughout glioblastoma development. Nat Immunol. 2022;23(6):971–84.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gajewski TF, Schreiber H, Fu YX. Innate and adaptive immune cells within the tumor microenvironment. Nat Immunol. 2013;14(10):1014–22.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Christofides A, Strauss L, Yeo A, Cao C, Charest A, Boussiotis VA. The advanced function of tumor-infiltrating macrophages. Nat Immunol. 2022;23(8):1148–56.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu Y, Cao X. Traits and significance of the pre-metastatic area of interest. Most cancers Cell. 2016;30(5):668–81.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Xu X, Zhang M, Xu F, Jiang S. Wnt signaling in breast most cancers: organic mechanisms, challenges and alternatives. Mol Most cancers. 2020;19(1):165.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Liu Y, Zhang Q, Xing B, Luo N, Gao R, Yu Okay, Hu X, Bu Z, Peng J, Ren X, et al. Immune phenotypic linkage between colorectal most cancers and liver metastasis. Most cancers Cell. 2022;40(4):424–e437425.

    Article 
    PubMed 

    Google Scholar
     

  • Wu Y, Yang S, Ma J, Chen Z, Tune G, Rao D, Cheng Y, Huang S, Liu Y, Jiang S, et al. Spatiotemporal Immune Panorama of Colorectal Most cancers Liver Metastasis at single-cell stage. Most cancers Discov. 2022;12(1):134–53.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Tao W, Chu C, Zhou W, Huang Z, Zhai Okay, Fang X, Huang Q, Zhang A, Wang X, Yu X, et al. Twin function of WISP1 in sustaining glioma stem cells and tumor-supportive macrophages in glioblastoma. Nat Commun. 2020;11(1):3015.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zhou Y, Meng X, He W, Li X, Zhao R, Dong C, Yuan D, Yang J, Zhang R, Shi G, et al. USF1/CD90 signaling in sustaining glioblastoma stem cells and tumor-associated macrophages adhesion. Neurooncology. 2022;24(9):1482–93.

    CAS 

    Google Scholar
     

  • Cheng Y, Bai F, Ren X, Solar R, Guo X, Liu W, Wang B, Yang Y, Zhang X, Xu Y, et al. Phosphoinositide-binding protein TIPE1 promotes various activation of macrophages and Tumor Development by way of PIP3/Akt/TGFβ Axis. Most cancers Res. 2022;82(8):1603–16.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Li D, Zhang Q, Li L, Chen Okay, Yang J, Dixit D, Gimple RC, Ci S, Lu C, Hu L, et al. beta2-Microglobulin maintains Glioblastoma Stem cells and induces M2-like polarization of Tumor-Related macrophages. Most cancers Res. 2022;82(18):3321–34.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Zhang L, Yu D. Exosomes in most cancers growth, metastasis, and immunity. Biochim et Biophys acta Evaluations most cancers. 2019;1871(2):455–68.

    Article 
    CAS 

    Google Scholar
     

  • Xue Z, Wang J, Wang Z, Liu J, Zhao J, Liu X, Zhang Y, Liu G, Zhao Z, Li W, et al. SLC25A32 promotes malignant development of glioblastoma by activating PI3K-AKT signaling pathway. BMC Most cancers. 2023;23(1):589.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Solar C, Mezzadra R, Schumacher TN. Regulation and performance of the PD-L1 checkpoint. Immunity. 2018;48(3):434–52.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Zou S, Tong Q, Liu B, Huang W, Tian Y, Fu X. Focusing on STAT3 in Most cancers Immunotherapy. Mol Most cancers. 2020;19(1):145.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bagchi S, Yuan R, Engleman EG. Immune Checkpoint inhibitors for the therapy of Most cancers: medical influence and mechanisms of response and resistance. Annu Rev Pathol. 2021;16:223–49.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

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