Tan H, Chen W, Liu Q, Yang G, Li Okay. Pectin oligosaccharides ameliorate Colon most cancers by regulating oxidative stress- and inflammation-activated signaling pathways. Entrance Immunol. 2018;9:1504.
Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L. Colombel. Ulcerative colitis. Lancet. 2017;389:1756–70.
Martini E, Krug SM, Siegmund B, Neurath MF, Becker C. Mend your fences: the epithelial barrier and its Relationship with Mucosal Immunity in Inflammatory Bowel Illness. Cell Mol Gastroenterol Hepatol. 2017;4:33–46.
Dotti I, Mora-Buch R, Ferrer-Picon E, Planell N, Jung P, Masamunt MC, Leal RF, de Carpi JM, Llach J, Ordas I, et al. Alterations within the epithelial stem cell compartment might contribute to everlasting adjustments within the mucosa of sufferers with ulcerative colitis. Intestine. 2017;66:2069–79.
Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel illness. Nature. 2011;474:307–17.
Peterson LW, Artis D. Intestinal epithelial cells: regulators of barrier operate and immune homeostasis. Nat Rev Immunol. 2014;14:141–53.
Nenci A, Becker C, Wullaert A, Gareus R, van Lavatory G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, et al. Epithelial NEMO hyperlinks innate immunity to power intestinal irritation. Nature. 2007;446:557–61.
Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, Might MJ, Greten FR, et al. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 2007;446:552–6.
Neurath MF. Concentrating on immune cell circuits and trafficking in inflammatory bowel illness. Nat Immunol. 2019;20:970–9.
Pan X, Zhu Q, Pan LL, Solar J. Macrophage immunometabolism in inflammatory bowel ailments: from pathogenesis to remedy. Pharmacol Ther. 2022;238:108176.
Harbord M, Eliakim R, Bettenworth D, Karmiris Okay, Katsanos Okay, Kopylov U, Kucharzik T, Molnar T, Raine T, Sebastian S, et al. Third European evidence-based Consensus on analysis and administration of Ulcerative Colitis. Half 2: present administration. J Crohns Colitis. 2017;11:769–84.
Alsoud D, Verstockt B, Fiocchi C, Vermeire S. Breaking the therapeutic ceiling in drug improvement in ulcerative colitis. Lancet Gastroenterol Hepatol. 2021;6:589–95.
Li TH, Liu L, Hou YY, Shen SN, Wang TT. C-type lectin receptor-mediated immune recognition and response of the microbiota within the intestine. Gastroenterol Rep (Oxf). 2019;7:312–21.
Walsh D, McCarthy J, O’Driscoll C, Melgar S. Sample recognition receptors–molecular orchestrators of irritation in inflammatory bowel illness. Cytokine Progress Issue Rev. 2013;24:91–104.
Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in ladies: a randomized medical trial. World J Urol. 2014;32:79–84.
Porru D, Parmigiani A, Tinelli C, Barletta D, Choussos D, Di Franco C, Bobbi V, Bassi S, Miller O, Gardella B, et al. Oral D-mannose in recurrent urinary tract infections in ladies: a pilot examine. J Clin Urol. 2014;7:208–13.
Relaxation RF, Farrell CF, Naids FL. Mannose inhibits the human neutrophil oxidative burst. J Leukoc Biol. 1988;43:158–64.
Xu XL, Xie QM, Shen YH, Jiang JJ, Chen YY, Yao HY. Zhou. Mannose prevents lipopolysaccharide-induced acute lung damage in rats. Inflamm Res. 2008;57:104–10.
Torretta S, Scagliola A, Ricci L, Mainini F, Di Marco S, Cuccovillo I, Kajaste-Rudnitski A, Sumpton D, Ryan KM. Cardaci. D-mannose suppresses macrophage IL-1beta manufacturing. Nat Commun. 2020;11:6343.
Zhang W, Cheng H, Gui Y, Zhan Q, Li S, Qiao W, Tong A. Mannose therapy: a Promising Novel Technique to suppress irritation. Entrance Immunol. 2021;12:756920.
Muller S, Schaffer T, Flogerzi B, Seibold-Schmid B, Schnider J, Takahashi Okay, Darfeuille-Michaud A, Vazeille E, Schoepfer AM, Seibold F. Mannan-binding lectin deficiency leads to uncommon antibody manufacturing and extreme experimental colitis in response to mannose-expressing gentle intestine pathogens. Intestine. 2010;59:1493–500.
Xiao P, Hu Z, Lang J, Pan T, Mertens RT, Zhang H, Guo Okay, Shen M, Cheng H, Zhang X, et al. Mannose metabolism normalizes intestine homeostasis by blocking the TNF-alpha-mediated proinflammatory circuit. Cell Mol Immunol. 2023;20:119–30.
Dong L, Xie J, Wang Y, Jiang H, Chen Okay, Li D, Wang J, Liu Y, He J, Zhou J, et al. Mannose ameliorates experimental colitis by defending intestinal barrier integrity. Nat Commun. 2022;13:4804.
Fanibunda SE, Modi DN, Gokral JS, Bandivdekar AH. HIV gp120 binds to mannose receptor on vaginal epithelial cells and induces manufacturing of matrix metalloproteinases. PLoS ONE. 2011;6:e28014.
Rudd PM, Wormald MR, Dwek RA. Sugar-mediated ligand-receptor interactions within the immune system. Traits Biotechnol. 2004;22:524–30.
Hu J, Wei P, Seeberger PH, Yin J. Mannose-functionalized nanoscaffolds for focused supply in Biomedical Purposes. Chem Asian J. 2018;13:3448–59.
Gan J, Liu C, Li H, Wang S, Wang Z, Kang Z, Huang Z, Zhang J, Wang C, Lv D, et al. Accelerated wound therapeutic in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors. Biomaterials. 2019;219:119340.
Gan J, Dou Y, Li Y, Wang Z, Wang L, Liu S, Li Q, Yu H, Liu C, Han C, et al. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials. 2018;178:95–108.
Yang H, Zhu C, Yuan W, Wei X, Liu C, Huang J, Yuan M, Wu Y, Ling Q, Hoffmann PR, et al. Mannose-rich oligosaccharides-functionalized selenium nanoparticles mediates macrophage reprogramming and irritation decision in ulcerative colitis. Chem Eng J. 2022;435:131715.
Yang H, Liu C, Wu Y, Yuan M, Huang J, Xia Y, Ling Q, Hoffmann PR, Huang Z, Chen T. Atherosclerotic plaque-targeted nanotherapeutics ameliorates atherogenesis by blocking macrophage-driven irritation. Nano Right this moment. 2022;42:101351.
Rayman MP. Selenium and human well being. Lancet. 2012;379:1256–68.
Huang Z, Rose AH, Hoffmann PR. The position of selenium in irritation and immunity: from molecular mechanisms to therapeutic alternatives. Antioxid Redox Sign. 2012;16:705–43.
Huang LJ, Mao XT, Li YY, Liu DD, Fan KQ, Liu RB, Wu TT, Wang HL, Zhang Y, Yang B, et al. Multiomics analyses reveal a vital position of selenium in controlling T cell differentiation in Crohn’s illness. Immunity. 2021;54:1728–44. e7.
Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014;94:739–77.
Castro Aguilar-Tablada T, Navarro-Alarcon M, Quesada Granados J, Samaniego Sanchez C, Rufian-Henares JA. and F. Nogueras-Lopez. Ulcerative Colitis and Crohn’s Illness Are Related to Decreased Serum Selenium Concentrations and Elevated Cardiovascular Threat. Vitamins. 2016; 8.
Krehl S, Loewinger M, Florian S, Kipp AP, Banning A, Wessjohann LA, Brauer MN, Iori R, Esworthy RS, Chu FF, et al. Glutathione peroxidase-2 and selenium decreased irritation and tumors in a mouse mannequin of inflammation-associated carcinogenesis whereas sulforaphane results differed with selenium provide. Carcinogenesis. 2012;33:620–8.
Wadhwani SA, Shedbalkar UU, Singh R, Chopade BA. Biogenic selenium nanoparticles: present standing and future prospects. Appl Microbiol Biotechnol. 2016;100:2555–66.
He L, Zhao J, Wang L, Liu Q, Fan Y, Li B, Yu YL, Chen C, Li YF. Utilizing nano-selenium to fight Coronavirus Illness 2019 (COVID-19)? Nano Right this moment. 2021;36:101037.
Qiao Q, Liu X, Yang T, Cui Okay, Kong L, Yang C, Zhang Z. Nanomedicine for acute respiratory misery syndrome: the most recent utility, focusing on technique, and rational design. Acta Pharm Sin B. 2021;11:3060–91.
Kumar A, Prasad KS. Position of nano-selenium in well being and atmosphere. J Biotechnol. 2021;325:152–63.
Guan B, Yan R, Li R, Zhang X. Selenium as a pleiotropic agent for medical discovery and drug supply. Int J Nanomed. 2018;13:7473–90.
Au A, Mojadadi A, Shao JY, Ahmad G. and P.Okay. Witting. Physiological advantages of Novel Selenium Supply by way of nanoparticles. Int J Mol Sci. 2023; 24.
Ye R, Guo Q, Huang J, Wang Z, Chen Y, Dong Y. Eucommia ulmoides polysaccharide modified nano-selenium successfully alleviated DSS-induced colitis by way of enhancing intestinal mucosal barrier operate and antioxidant capability. J Nanobiotechnol. 2023;21:222.
Laroui H, Dalmasso G, Nguyen HT, Yan Y, Sitaraman SV, Merlin D. Drug-loaded nanoparticles focused to the colon with polysaccharide hydrogel cut back colitis in a mouse mannequin. Gastroenterology. 2010;138:843–53. e1-2.
Yan YX, Shao MJ, Qi Q, Xu YS, Yang XQ, Zhu FH, He SJ, He PL, Feng CL, Wu YW, et al. Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis by way of suppressing neutrophils and macrophages. Acta Pharmacol Sin. 2018;39:1633–44.
Zhang L, Zhang Y, Zhong W, Di C, Lin X, Xia Z. Heme oxygenase-1 ameliorates dextran sulfate sodium-induced acute murine colitis by regulating Th17/Treg cell steadiness. J Biol Chem. 2014;289:26847–58.
Wirtz S, Neurath MF. Mouse fashions of inflammatory bowel illness. Adv Drug Deliv Rev. 2007;59:1073–83.
Huang Z, Pei Q, Solar G, Zhang S, Liang J, Gao Y, Zhang X. Low selenium standing impacts arsenic metabolites in an arsenic uncovered inhabitants with pores and skin lesions. Clin Chim Acta. 2008;387:139–44.
Kumagai H, Pham W, Kataoka M, Hiwatari Okay, McBride J, Wilson KJ, Tachikawa H, Kimura R, Nakamura Okay, Liu EH, et al. Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal most cancers. Int J Most cancers. 2013;132:2107–17.
Labruère R, Sicard R, Cormier R, Turos E, West L. Poly(vinyl benzoate) nanoparticles for molecular supply: research on their preparation and in vitro properties. J Managed Launch. 2010;148:234–40.
Zhu S, Xing H, Gordiichuk P, Park J. Mirkin. PLGA spherical nucleic acids. Adv Mater. 2018;30:e1707113.
Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, et al. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017;23:1036–45.
Ouyang J, Deng B, Zou B, Li Y, Bu Q, Tian Y, Chen M, Chen W, Kong N, Chen T, et al. Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota. J Am Chem Soc. 2023;145:12193–205.
Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription think about power inflammatory ailments. N Engl J Med. 1997;336:1066–71.
Neurath MF, Becker C, Barbulescu Okay. Position of NF-kappaB in immune and inflammatory responses within the intestine. Intestine. 1998;43:856–60.
Rogler G, Model Okay, Vogl D, Web page S, Hofmeister R, Andus T, Knuechel R, Baeuerle PA, Scholmerich J. Gross. Nuclear issue kappaB is activated in macrophages and epithelial cells of infected intestinal mucosa. Gastroenterology. 1998;115:357–69.
Wullaert A, Bonnet MC, Pasparakis M. NF-kappaB within the regulation of epithelial homeostasis and irritation. Cell Res. 2011;21:146–58.
Peng SJ, Ye DT, Zheng J, Xue YR, Lin L, Zhao YD, Miao WH, Track Y, Wen ZS. and B. Zheng. Synthesis, characterization of low Molecular Weight Chitosan Selenium nanoparticles and its Impact on DSS-Induced Ulcerative Colitis in mice. Int J Mol Sci. 2022; 23.
Sharma V, Ichikawa M, Freeze HH. Mannose metabolism: greater than meets the attention. Biochem Biophys Res Commun. 2014;453:220–8.
van der Zande HJP, Nitsche D, Schlautmann L, Guigas B, Burgdorf S. The mannose receptor: from endocytic receptor and biomarker to Regulator of (Meta)irritation. Entrance Immunol. 2021;12:765034.
Liu P, Gao C, Chen H, Vong CT, Wu X, Tang X, Wang S, Wang Y. Receptor-mediated focused drug supply methods for therapy of inflammatory bowel illness: alternatives and rising methods. Acta Pharm Sin B. 2021;11:2798–818.
Barrett CW, Singh Okay, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, et al. Dietary selenium deficiency exacerbates DSS-induced epithelial damage and AOM/DSS-induced tumorigenesis. PLoS ONE. 2013;8:e67845.
Esworthy RS, Aranda R, Martin MG, Doroshow JH, Binder SW. Chu. Mice with mixed disruption of Gpx1 and Gpx2 genes have colitis. Am J Physiol Gastrointest Liver Physiol. 2001;281:G848–55.
Chu FF, Esworthy RS, Chu PG, Longmate JA, Huycke MM, Wilczynski S. Doroshow. Micro organism-induced intestinal most cancers in mice with disrupted Gpx1 and Gpx2 genes. Most cancers Res. 2004;64:962–8.
Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, et al. Tumor suppressor operate of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Most cancers Res. 2013;73:1245–55.
Yokote A, Imazu N, Umeno J, Kawasaki Okay, Fujioka S, Fuyuno Y, Matsuno Y, Moriyama T, Miyawaki Okay, Akashi Okay, et al. Ferroptosis within the colon epithelial cells as a therapeutic goal for ulcerative colitis. J Gastroenterol. 2023;58:868–82.
Khazdouz M, Daryani NE, Cheraghpour M, Alborzi F, Hasani M, Ghavami SB, Shidfar F. The impact of selenium supplementation on illness exercise and immune-inflammatory biomarkers in sufferers with mild-to-moderate ulcerative colitis: a randomized, double-blind, placebo-controlled medical trial. Eur J Nutr. 2023;62:3125–34.
Chen N, Yao P, Zhang W, Zhang Y, Xin N, Wei H, Zhang T, Zhao C. Selenium nanoparticles: enhanced vitamin and past. Crit Rev Meals Sci Nutr. 2023;63:12360–71.